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Study Information
Study Attribute Value
CEBS Accession Number: 002-01349-0001-0000-0
Chemical Name: 2-Methyl-1-nitroanthraquinone
CASRN: 129-15-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 565805_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 11/17/1987    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 435 0.415 8.70 26.0 0.000
Test Chemical 2-Methyl-1-nitroanthraquinone 
 0.5       
 50 1047 814 0.777 16.28 26.0 87.484 
1.6       
 25 521 668 1.282 26.72 26.0 209.190 
5         
 25 523 808 1.545 32.32 26.0 272.560 
10         
 25 525 679 1.293 27.16 26.0 211.887
Positive Control Mitomycin-C 
 0.0E-4    
 50 1039 591 0.569 11.82 26.0 37.170
Mitomycin-C 
 0.005     
 10 210 194 0.924 19.40 26.0 122.776
Trend: 24.380        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 12/22/1987    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1047 468 0.447 9.36 26.0 0.000
Test Chemical 2-Methyl-1-nitroanthraquinone 
 0.5       
 50 1045 742 0.710 14.84 26.0 58.850 
1.6       
 50 1049 948 0.904 18.96 26.0 102.178 
5         
 10 211 280 1.327 28.00 26.0 196.877 
10         
 25 519 623 1.200 24.92 26.0 168.548
Positive Control Mitomycin-C 
 0.0E-4    
 50 1043 574 0.550 11.48 26.0 23.120
Mitomycin-C 
 0.005     
 10 210 273 1.300 27.30 26.0 190.833
Trend: 18.783        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 11/17/1987    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1051 432 0.411 8.64 26.0 0.000
Test Chemical 2-Methyl-1-nitroanthraquinone 
 0.5       
 50 1045 453 0.433 9.06 26.0 5.463 
1.6       
 50 1041 481 0.462 9.62 26.0 12.412 
5         
 50 1049 773 0.737 15.46 26.0 79.276 
10         
 50 1043 1083 1.038 21.66 26.0 152.617
Positive Control Cyclophosphamide 
 0.1       
 50 1046 546 0.522 10.92 26.0 26.993
Cyclophosphamide 
 0.6       
 10 210 193 0.919 19.30 26.0 123.592
Trend: 19.767        
Probability: 0.000