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Study Information
Study Attribute Value
CEBS Accession Number: 002-01349-0002-0000-1
Chemical Name: 2-Methyl-1-nitroanthraquinone
CASRN: 129-15-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 565805_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Weakly Positive* 

Trial #:1   Activation: No Activation    Date: 12/17/1987    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0
Test Chemical: 2-Methyl-1-nitroanthraquinone 
1.6       
 200 6 0.030 3.0 0 0.000 0.0 6 0.030 3.0 0 0.000 0.0 
5         
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0 
10         
 200 4 0.020 2.0 0 0.000 0.0 4 0.020 2.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.0625    
 200 23 0.115 10.0 2 0.010 1.0 21 0.105 9.0 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 18 0.360 32.0 4 0.080 6.0 14 0.280 28.0 0 0.000 0.0
Trend: -0.053 0.000 -0.053  
Probability: 0.521 0.000 0.521  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 01/12/1988    Harvest Time: 13 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 2-Methyl-1-nitroanthraquinone 
3         
 200 6 0.030 3.0 1 0.005 0.5 5 0.025 2.5 0 0.000 0.0 
5         
 200 10 0.050 5.0 2 0.010 1.0 8 0.040 4.0 0 0.000 0.0 
10         
 200 19 0.095 9.5 4 0.020 2.0 15 0.075 7.5 0 0.000 0.0
Positive Control: Cyclophosphamide 
2.5       
 200 24 0.120 11.0 2 0.010 0.5 22 0.110 11.0 0 0.000 0.0
Cyclophosphamide 
7.5       
 50 21 0.420 42.0 4 0.080 8.0 17 0.340 34.0 0 0.000 0.0
Trend: 4.750 2.224 4.160  
Probability: 0.000 0.013 0.000  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 12/17/1987    Harvest Time: 13 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 4 0.020 2.0 0 0.000 0.0 4 0.020 2.0 0 0.000 0.0
Test Chemical: 2-Methyl-1-nitroanthraquinone 
1.6       
 200 5 0.025 2.0 2 0.010 0.5 3 0.015 1.5 0 0.000 0.0 
5         
 200 6 0.030 3.0 2 0.010 1.0 4 0.020 2.0 0 0.000 0.0 
10         
 200 21 0.105 10.5 7 0.035 3.5 14 0.070 7.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
5         
 200 15 0.075 7.0 4 0.020 2.0 11 0.055 5.5 0 0.000 0.0
Cyclophosphamide 
7.5       
 50 19 0.380 36.0 1 0.020 2.0 18 0.360 34.0 0 0.000 0.0
Trend: 3.883 3.011 2.642  
Probability: 0.000 0.001 0.004