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Study Information
Study Attribute Value
CEBS Accession Number: 002-01364-0001-0000-7
Chemical Name: 2-Naphthylamine
CASRN: 91-59-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 829306_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Questionable 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Negative 
Induced Rat Liver S9  2_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 07/16/1985    Trial Call: Questionable   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1047 512 0.489 10.24 26.0 0.000
Test Chemical 2-Naphthylamine 
5         
 50 1049 482 0.459 9.64 26.0 -6.039 
16         
 50 1051 512 0.487 10.24 26.0 -0.381 
50         
 50 1049 601 0.573 12.02 31.0 17.159 
160         
 0 0 0 0.000 0.00 36.0 N/A
Positive Control Mitomycin-C 
 0.0E-4    
 50 1050 626 0.596 12.52 26.0 21.916
Mitomycin-C 
 0.005     
 10 210 301 1.433 30.10 26.0 193.105
Trend: 2.847        
Probability: 0.002        

Trial #: 2    Activation: No Activation    Date: 08/27/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 443 0.422 8.86 26.0 0.000
Test Chemical 2-Naphthylamine 
50         
 50 1050 578 0.550 11.56 31.0 30.350 
75         
 50 1048 688 0.656 13.76 31.0 55.453
Positive Control Mitomycin-C 
 0.0E-4    
 50 1049 582 0.555 11.64 26.0 31.377
Mitomycin-C 
 0.005     
 10 210 230 1.095 23.00 26.0 159.346
Trend: 7.276        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 06/17/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1044 462 0.443 9.24 26.0 0.000
Test Chemical 2-Naphthylamine 
 0.5       
 50 1047 471 0.450 9.42 26.0 1.656 
1.6       
 50 1048 499 0.476 9.98 26.0 7.596 
5         
 33 690 334 0.484 10.12 26.0 9.385 
16         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Cyclophosphamide 
 0.2       
 50 1048 958 0.914 19.16 26.0 106.568
Cyclophosphamide 
 0.6       
 10 210 334 1.590 33.40 26.0 259.406
Trend: 1.489        
Probability: 0.068        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 07/16/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 444 0.423 8.88 26.0 0.000
Test Chemical 2-Naphthylamine 
 0.16      
 50 1050 463 0.441 9.26 26.0 4.279 
 0.5       
 50 1047 518 0.495 10.36 26.0 17.001 
1.6       
 50 1048 481 0.459 9.62 26.0 8.540 
5         
 0 0 0 0.000 0.00 31.0 N/A
Positive Control Cyclophosphamide 
 0.2       
 50 1049 1156 1.102 23.12 26.0 160.609
Cyclophosphamide 
 0.6       
 10 208 364 1.750 36.40 26.0 313.851
Trend: 1.734        
Probability: 0.041