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Study Information
Study Attribute Value
CEBS Accession Number: 002-01364-0002-0000-8
Chemical Name: 2-Naphthylamine
CASRN: 91-59-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 829306_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Weakly Positive* 
Induced Rat Liver S9  2_S9  Positive 

Trial #:1   Activation: No Activation    Date: 10/29/1985    Harvest Time: 22 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 4 0.020 2.0 0 0.000 0.0 4 0.020 2.0 0 0.000 0.0
Test Chemical: 2-Naphthylamine 
100         
 200 5 0.025 2.5 2 0.010 1.0 3 0.015 1.5 0 0.000 0.0 
160         
 200 4 0.020 2.0 1 0.005 0.5 3 0.015 1.5 0 0.000 0.0 
300         
 200 9 0.045 4.5 2 0.010 1.0 7 0.035 3.5 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.03      
 200 34 0.170 15.5 10 0.050 5.0 24 0.120 11.0 0 0.000 0.0
Mitomycin-C 
 0.0625    
 50 32 0.640 42.0 11 0.220 16.0 21 0.420 34.0 0 0.000 0.0
Trend: 1.414 1.031 1.040  
Probability: 0.079 0.151 0.149  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 11/20/1985    Harvest Time: 18 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0
Test Chemical: 2-Naphthylamine 
100         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
160         
 200 9 0.045 4.5 4 0.020 2.0 5 0.025 2.5 0 0.000 0.0 
200         
 200 69 0.345 23.5 15 0.075 6.5 54 0.270 20.0 0 0.000 0.0 
300         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
5         
 200 223 1.115 54.5 74 0.370 28.5 89 0.445 36.0 60 0.300 6.0
Cyclophosphamide 
7.5       
 50 122 2.440 86.0 47 0.940 54.0 55 1.100 66.0 20 0.400 2.0
Trend: 7.878 4.473 7.027  
Probability: 0.000 0.000 0.000  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 10/31/1985    Harvest Time: 18 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: 2-Naphthylamine 
100         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0 
160         
 200 13 0.065 5.0 9 0.045 3.0 4 0.020 2.0 0 0.000 0.0 
300         
 200 125 0.625 37.0 28 0.140 11.0 95 0.475 32.0 2 0.010 2.0
Positive Control: Cyclophosphamide 
5         
 200 142 0.710 47.0 53 0.265 24.0 79 0.395 32.5 10 0.050 1.0
Cyclophosphamide 
7.5       
 50 104 2.080 80.0 32 0.640 46.0 32 0.640 44.0 40 0.800 4.0
Trend: 11.855 6.301 10.982  
Probability: 0.000 0.000 0.000