Genetic Toxicology - Rodent Cytogenetics

Study Information
Study Attribute	Value
CEBS Accession Number:	002-01364-0007-0000-3
Chemical Name:	2-Naphthylamine
CASRN:	91-59-8
NTP Study Type:	Genetic Toxicology - Rodent Cytogenetics
NTP Study ID:	080086_SCE
Study Result:	Positive

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Table Instructions and Notes:

Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.

Summary of Sister Chromatid Exchange Data (Trial 1)
Test Type	Start Date	Sample Time (h)	Species	Sex	Strain	Tissue	Protocol	Trend Test P
SCE	03/21/85	23	Mouse	Male	B6C3F1	Bone Marrow	IP/IJ x 1, 23 hour

		Dose (mg/kg)	n	SCE / Cell (Mean ± SEM)
Vehicle Control	Dimethyl Sulfoxide	0	4	5.00 ± 0.432
Test Chemical	2-Naphthylamine	87.5	4	6.76 ± 0.617
		175	4	7.00 ± 0.233
		350	4	10.97 ± 1.146
Positive Control	Dimethylbenzanthracene	2.5	4	13.66 ± 1.732

Summary of Sister Chromatid Exchange Data (Trial 2)
Test Type	Start Date	Sample Time (h)	Species	Sex	Strain	Tissue	Protocol	Trend Test P
SCE	12/02/87	42	Mouse	Male	B6C3F1	Bone Marrow	IP/IJ x 1, 42 hour

		Dose (mg/kg)	n	SCE / Cell (Mean ± SEM)
Vehicle Control	Dimethyl Sulfoxide	0	4	5.67 ± 0.264
Test Chemical	2-Naphthylamine	87.5	4	5.49 ± 0.573
		175	4	7.34 ± 1.072
		350	7	8.27 ± 0.762
Positive Control	Dimethylbenzanthracene	2.5	4	12.70 ± 1.181

Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed