COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-01371-0001-0000-5
Chemical Name: 2-Nitropropane
CASRN: 79-46-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 437563_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 01/20/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1048 512 0.489 10.24 26.0 0.000
Test Chemical 2-Nitropropane 
160         
 40 829 378 0.456 9.45 26.0 -6.668 
500         
 50 1050 471 0.449 9.42 26.0 -8.183 
1600         
 50 1048 534 0.510 10.68 26.0 4.297
Positive Control Mitomycin-C 
 0.005     
 50 1050 846 0.806 16.92 26.0 64.920
Trend: 0.546        
Probability: 0.292        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 01/20/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 480 0.457 9.60 26.0 0.000
Test Chemical 2-Nitropropane 
500         
 50 1047 410 0.392 8.20 26.0 -14.339 
1600         
 50 1044 496 0.475 9.92 26.0 3.927 
5000         
 50 1048 477 0.455 9.54 26.0 -0.435
Positive Control Cyclophosphamide 
1         
 25 526 540 1.027 21.60 26.0 124.572
Trend: 0.845        
Probability: 0.199