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Study Information
Study Attribute Value
CEBS Accession Number: 002-01371-0002-0000-6
Chemical Name: 2-Nitropropane
CASRN: 79-46-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 437563_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 01/20/1982    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 4 0.040 4.0 0 0.000 0.0 4 0.040 4.0 0 0.000 0.0
Test Chemical: 2-Nitropropane 
500         
 100 7 0.070 7.0 0 0.000 0.0 7 0.070 7.0 0 0.000 0.0 
1600         
 100 4 0.040 4.0 0 0.000 0.0 4 0.040 4.0 0 0.000 0.0 
5000         
 100 4 0.040 4.0 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.15      
 100 23 0.230 19.0 7 0.070 7.0 16 0.160 13.0 0 0.000 0.0
Trend: -0.317 1.897 -0.997  
Probability: 0.624 0.029 0.841  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 01/20/1982    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 6 0.060 5.0 0 0.000 0.0 6 0.060 5.0 0 0.000 0.0
Test Chemical: 2-Nitropropane 
500         
 100 6 0.060 6.0 1 0.010 1.0 5 0.050 5.0 0 0.000 0.0 
1600         
 100 7 0.070 6.0 1 0.010 1.0 6 0.060 5.0 0 0.000 0.0 
5000         
 100 8 0.080 7.0 0 0.000 0.0 8 0.080 7.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
15         
 100 31 0.310 26.0 10 0.100 10.0 21 0.210 19.0 0 0.000 0.0
Trend: 0.564 0.003 0.587  
Probability: 0.286 0.499 0.279