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Study Information
Study Attribute Value
CEBS Accession Number: 002-01381-0001-0000-6
Chemical Name: 3'-Azido-3'-deoxythymidine (AIDS)
CASRN: 30516-87-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 476222_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 01/04/1990    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1049 363 0.346 7.26 26.0 -5.804
Dimethyl Sulfoxide 
0         
 50 1048 385 0.367 7.70 26.0 0.000
Test Chemical 3'-Azido-3'-deoxythymidine (AIDS) 
8.3       
 50 1049 715 0.682 14.30 26.0 85.537 
25         
 50 1049 918 0.875 18.36 26.0 138.214 
83         
 25 525 538 1.025 21.52 26.0 178.948 
250         
 0 0 0 0.000 0.00 31.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1047 687 0.656 13.74 26.0 78.612
Mitomycin-C 
 0.004     
 10 208 187 0.899 18.70 26.0 144.725
Trend: 16.813        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 01/23/1990    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 384 0.366 7.68 26.0 0.000
Negative (Not Specified) 
0         
 50 1049 397 0.378 7.94 26.0 3.385
Test Chemical 3'-Azido-3'-deoxythymidine (AIDS) 
8.3       
 50 1049 564 0.538 11.28 26.0 46.875 
25         
 50 1047 645 0.616 12.90 26.0 68.290 
83         
 25 522 481 0.921 19.24 26.0 151.721 
250         
 0 0 0 0.000 0.00 31.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1051 532 0.506 10.64 26.0 38.278
Mitomycin-C 
 0.004     
 10 210 186 0.886 18.60 26.0 141.957
Trend: 13.577        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 01/04/1990    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1044 402 0.385 8.04 26.0 5.587
Dimethyl Sulfoxide 
0         
 50 1042 380 0.365 7.60 26.0 0.000
Test Chemical 3'-Azido-3'-deoxythymidine (AIDS) 
250         
 50 1050 443 0.422 8.86 26.0 15.691 
833         
 50 1049 479 0.457 9.58 26.0 25.211 
2500         
 50 1047 551 0.526 11.02 26.0 44.308
Positive Control Cyclophosphamide 
 0.125     
 50 1049 670 0.639 13.40 26.0 75.139
Cyclophosphamide 
 0.5       
 10 210 204 0.971 20.40 26.0 166.376
Trend: 5.632        
Probability: 0.000