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Study Information
Study Attribute Value
CEBS Accession Number: 002-01389-0002-0000-5
Chemical Name: 3,3'-Dimethoxybenzidine
CASRN: 119-90-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 013473_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 09/25/1980    Harvest Time: 10 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 0 0.000 0.0 1 0.010 1.0 1 0.010 1.0
Test Chemical: 3,3'-Dimethoxybenzidine 
6.25      
 100 8 0.080 2.0 0 0.000 0.0 8 0.080 2.0 0 0.000 0.0 
12.5       
 100 4 0.040 4.0 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0 
25         
 100 6 0.060 4.0 3 0.030 2.0 3 0.030 3.0 0 0.000 0.0 
50         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0 
100         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 
200         
 100 12 0.120 11.0 2 0.020 2.0 9 0.090 8.0 0 0.000 0.0
Positive Control: Triethylenemelamine 
 0.25      
 49 61 1.245 69.0 23 0.469 35.0 37 0.755 51.0 1 0.020 2.0
Trend: 2.398 1.245 2.087  
Probability: 0.008 0.107 0.018  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 11/20/1980    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: 3,3'-Dimethoxybenzidine 
125         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0 
250         
 100 4 0.040 4.0 4 0.040 4.0 0 0.000 0.0 0 0.000 0.0 
500         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
2500         
 100 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0 0 0.000 0.0 
5000         
 100 4 0.040 3.0 2 0.020 2.0 2 0.020 1.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
25         
 100 73 0.730 45.0 28 0.280 24.0 43 0.430 29.0 2 0.020 2.0
Trend: 0.417 0.720 -0.415  
Probability: 0.338 0.236 0.661