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Study Information
Study Attribute Value
CEBS Accession Number: 002-01390-0002-0000-7
Chemical Name: 3,3'-Dimethoxybenzidine-4,4'-diisocyanate
CASRN: 91-93-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 921234_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Weakly Positive* 
No Activation  2  Positive 

Trial #:1   Activation: No Activation    Date: 09/19/1989    Harvest Time: 19 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Negative (Not Specified) 
0         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 3,3'-Dimethoxybenzidine-4,4'-diisocyanate 
150         
 100 27 0.270 23.0 14 0.140 14.0 13 0.130 11.0 0 0.000 0.0 
175         
 100 25 0.250 23.0 14 0.140 14.0 11 0.110 9.0 0 0.000 0.0 
200         
 100 28 0.280 23.0 15 0.150 14.0 13 0.130 10.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.4       
 25 62 2.480 72.0 22 0.880 44.0 9 0.360 28.0 31 1.240 16.0
Trend: 6.157 4.660 3.716  
Probability: 0.000 0.000 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 08/24/1989    Harvest Time: 14 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 3 0.015 1.5 3 0.015 1.5 0 0.000 0.0 0 0.000 0.0
Negative (Not Specified) 
0         
 200 4 0.020 2.0 4 0.020 2.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 3,3'-Dimethoxybenzidine-4,4'-diisocyanate 
9.4       
 200 6 0.030 3.0 2 0.010 1.0 4 0.020 2.0 0 0.000 0.0 
20         
 200 8 0.040 3.5 7 0.035 3.0 1 0.005 0.5 0 0.000 0.0 
43         
 200 45 0.225 19.5 32 0.160 14.5 13 0.065 5.5 0 0.000 0.0 
93         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
 0.5       
 25 19 0.760 56.0 14 0.560 48.0 5 0.200 2.0 0 0.000 0.0
Trend: 6.818 5.953 3.395  
Probability: 0.000 0.000 0.000  


Trial #:2   Activation: No Activation    Date: 08/24/1989    Harvest Time: 19 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Test Chemical: 3,3'-Dimethoxybenzidine-4,4'-diisocyanate 
43         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0 
93         
 200 15 0.075 7.0 8 0.040 3.5 7 0.035 3.5 0 0.000 0.0 
200         
 50 52 1.040 52.0 14 0.280 28.0 18 0.360 20.0 20 0.400 4.0
Positive Control: Mitomycin-C 
 0.4       
 25 20 0.800 48.0 8 0.320 28.0 12 0.480 36.0 0 0.000 0.0
Trend: 0.000 0.000 0.000  
Probability: 0.000 0.000 0.000