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Study Information
Study Attribute Value
CEBS Accession Number: 002-01391-0001-0000-7
Chemical Name: 3,3'-Dimethylbenzidine
CASRN: 119-93-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 520009_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 12/16/1981    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1014 402 0.396 8.04 25.5 0.000
Test Chemical 3,3'-Dimethylbenzidine 
5         
 50 1014 525 0.518 10.50 25.5 30.597 
16.7       
 50 1010 611 0.605 12.22 25.5 52.592 
50         
 50 1006 879 0.874 17.58 30.5 120.396
Positive Control Mitomycin-C 
 0.005     
 25 512 745 1.455 29.80 25.5 267.027
Trend: 13.895        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 12/16/1981    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1045 527 0.504 10.54 25.5 0.000
Test Chemical 3,3'-Dimethylbenzidine 
500         
 50 1031 748 0.726 14.96 25.5 43.863 
1670         
 24 489 505 1.033 21.04 25.5 104.780 
5000         
 50 1016 886 0.872 17.72 25.5 72.920
Positive Control Cyclophosphamide 
1.5       
 50 1044 1353 1.296 27.06 25.5 156.982
Trend: 10.762        
Probability: 0.000