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Study Information
Study Attribute Value
CEBS Accession Number: 002-01396-0001-0000-2
Chemical Name: 3,4,5-Trichlorophenol
CASRN: 609-19-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 664293_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 12/02/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1022 389 0.381 7.78 26.0 0.000
Test Chemical 3,4,5-Trichlorophenol 
 0.5       
 50 1013 446 0.440 8.92 26.0 15.672 
1.67      
 50 1007 436 0.433 8.72 26.0 13.752 
5         
 50 1013 439 0.433 8.78 26.0 13.856 
16.7       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1022 530 0.519 10.60 26.0 36.247
Mitomycin-C 
 0.01      
 5 102 176 1.725 35.20 26.0 353.329
Trend: 1.672        
Probability: 0.047        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 12/02/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1016 478 0.470 9.56 26.0 0.000
Test Chemical 3,4,5-Trichlorophenol 
 0.5       
 50 1028 433 0.421 8.66 26.0 -10.472 
1.67      
 50 1009 487 0.483 9.74 26.0 2.590 
5         
 50 1026 447 0.436 8.94 26.0 -7.397 
16.7       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1029 606 0.589 12.12 26.0 25.177
Cyclophosphamide 
2         
 5 101 217 2.149 43.40 26.0 356.672
Trend: -0.429        
Probability: 0.666