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Study Information
Study Attribute Value
CEBS Accession Number: 002-01396-0002-0000-3
Chemical Name: 3,4,5-Trichlorophenol
CASRN: 609-19-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 664293_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 01/08/1986    Harvest Time: 20 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 4 0.020 2.0 2 0.010 1.0 2 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 3,4,5-Trichlorophenol 
15         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
22.4       
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0 
30         
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0 
40         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.05      
 200 37 0.185 14.5 19 0.095 8.5 18 0.090 8.5 0 0.000 0.0
Mitomycin-C 
 0.08      
 25 17 0.680 48.0 12 0.480 48.0 5 0.200 16.0 0 0.000 0.0
Trend: 2.215 0.000 2.215  
Probability: 0.013 0.000 0.013  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 01/07/1986    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 3 0.015 1.5 1 0.005 0.5 2 0.010 1.0 0 0.000 0.0
Test Chemical: 3,4,5-Trichlorophenol 
15         
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 
22.4       
 200 16 0.080 3.0 2 0.010 1.0 4 0.020 1.5 10 0.050 0.5 
30         
 200 3 0.015 1.0 1 0.005 0.5 2 0.010 0.5 0 0.000 0.0 
40         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
7.5       
 200 22 0.110 8.0 7 0.035 3.0 15 0.075 6.0 0 0.000 0.0
Cyclophosphamide 
37.5       
 25 10 0.400 32.0 4 0.160 12.0 6 0.240 20.0 0 0.000 0.0
Trend: 0.229 0.242 -0.098  
Probability: 0.409 0.404 0.539