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Study Information
Study Attribute Value
CEBS Accession Number: 002-01402-0002-0000-1
Chemical Name: 3,4-Dichloronitrobenzene
CASRN: 99-54-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 759890_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 03/13/1985    Harvest Time: 21.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 3,4-Dichloronitrobenzene 
150         
 100 6 0.060 6.0 4 0.040 4.0 1 0.010 1.0 1 0.010 1.0 
175         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0 
200         
 100 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0 0 0.000 0.0 
250         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.05      
 100 12 0.120 12.0 8 0.080 8.0 4 0.040 4.0 0 0.000 0.0
Mitomycin-C 
 0.08      
 25 14 0.560 44.0 5 0.200 20.0 9 0.360 24.0 0 0.000 0.0
Trend: -0.639 -0.438 -0.397  
Probability: 0.739 0.669 0.654  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 03/14/1985    Harvest Time: 12.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 9 0.090 6.0 3 0.030 3.0 6 0.060 5.0 0 0.000 0.0
Test Chemical: 3,4-Dichloronitrobenzene 
150         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 
175         
 100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0 
200         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0 
250         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
7.5       
 100 8 0.080 8.0 1 0.010 1.0 7 0.070 7.0 0 0.000 0.0
Cyclophosphamide 
37.5       
 25 25 1.000 40.0 3 0.120 8.0 11 0.440 24.0 11 0.440 8.0
Trend: -1.861 -1.831 -1.707  
Probability: 0.969 0.966 0.956