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Study Information
Study Attribute Value
CEBS Accession Number: 002-01404-0002-0000-3
Chemical Name: 3,4-Dihydrocoumarin
CASRN: 119-84-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 733791_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 07/16/1986    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 3 0.015 1.5 1 0.005 0.5 2 0.010 1.0 0 0.000 0.0
Test Chemical: 3,4-Dihydrocoumarin 
100         
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0 
160         
 200 4 0.020 1.5 0 0.000 0.0 4 0.020 1.5 0 0.000 0.0 
500         
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0 
1000         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.0625    
 200 30 0.150 13.0 8 0.040 4.0 22 0.110 9.5 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 27 0.540 34.0 14 0.280 22.0 13 0.260 26.0 0 0.000 0.0
Trend: 0.000 -1.272 0.386  
Probability: 0.500 0.898 0.350  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 07/16/1986    Harvest Time: 13 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: 3,4-Dihydrocoumarin 
500         
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0 
1000         
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 
1600         
 200 5 0.025 2.5 2 0.010 1.0 3 0.015 1.5 0 0.000 0.0 
3000         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
2.5       
 200 36 0.180 16.5 5 0.025 2.5 31 0.155 14.5 0 0.000 0.0
Cyclophosphamide 
5         
 50 11 0.220 22.0 5 0.100 10.0 6 0.120 12.0 0 0.000 0.0
Trend: 1.425 1.792 0.566  
Probability: 0.077 0.037 0.286