COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-01421-0001-0000-1
Chemical Name: 3-Amino-9-ethylcarbazole HCl
CASRN: 6109-97-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 688225_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 01/06/1987    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 392 0.373 7.84 26.0 0.000
Test Chemical 3-Amino-9-ethylcarbazole HCl 
 0.16      
 50 1050 381 0.363 7.62 26.0 -2.806 
 0.5       
 50 1050 458 0.436 9.16 26.0 16.837 
1.6       
 50 1050 470 0.448 9.40 26.0 19.898 
5         
 50 1050 502 0.478 10.04 26.0 28.061 
16         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Mitomycin-C 
 0.0E-4    
 50 1050 513 0.489 10.26 26.0 30.867
Mitomycin-C 
 0.005     
 10 209 246 1.177 24.60 26.0 215.277
Trend: 4.653        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 01/06/1987    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1043 376 0.360 7.52 26.0 0.000
Test Chemical 3-Amino-9-ethylcarbazole HCl 
1.6       
 50 1050 476 0.453 9.52 26.0 25.752 
5         
 50 1049 611 0.582 12.22 26.0 61.571 
16         
 50 1049 678 0.646 13.56 26.0 79.288 
50         
 50 1049 693 0.661 13.86 26.0 83.254
Positive Control Cyclophosphamide 
 0.1       
 50 1042 545 0.523 10.90 26.0 45.086
Cyclophosphamide 
 0.6       
 10 210 185 0.881 18.50 26.0 144.371
Trend: 11.031        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 03/24/1987    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 495 0.471 9.90 26.0 0.000
Test Chemical 3-Amino-9-ethylcarbazole HCl 
1.6       
 50 1050 507 0.483 10.14 26.0 2.424 
5         
 50 1050 571 0.544 11.42 26.0 15.354 
16         
 50 1050 687 0.654 13.74 26.0 38.788 
50         
 50 1050 830 0.790 16.60 26.0 67.677
Positive Control Cyclophosphamide 
 0.1       
 50 1050 661 0.630 13.22 26.0 33.535
Cyclophosphamide 
 0.6       
 10 210 243 1.157 24.30 26.0 145.455
Trend: 10.815        
Probability: 0.000