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Study Information
Study Attribute Value
CEBS Accession Number: 002-01421-0002-0000-2
Chemical Name: 3-Amino-9-ethylcarbazole HCl
CASRN: 6109-97-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 688225_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Questionable 
Induced Rat Liver S9  2_S9  Negative 

Trial #:1   Activation: No Activation    Date: 04/01/1987    Harvest Time: 12.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
Test Chemical: 3-Amino-9-ethylcarbazole HCl 
30         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0 
50         
 200 4 0.020 1.5 0 0.000 0.0 4 0.020 1.5 0 0.000 0.0 
100         
 200 7 0.035 3.0 0 0.000 0.0 7 0.035 3.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.0625    
 200 59 0.295 21.0 21 0.105 9.5 38 0.190 16.0 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 25 0.500 42.0 9 0.180 16.0 16 0.320 28.0 0 0.000 0.0
Trend: 1.846 -0.419 2.054  
Probability: 0.032 0.662 0.020  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 04/01/1987    Harvest Time: 13 hour(s)   Trial Call: Questionable   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: 3-Amino-9-ethylcarbazole HCl 
16         
 200 5 0.025 2.0 1 0.005 0.5 4 0.020 2.0 0 0.000 0.0 
30         
 200 7 0.035 3.5 0 0.000 0.0 7 0.035 3.5 0 0.000 0.0 
50         
 200 4 0.020 2.0 0 0.000 0.0 4 0.020 2.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
2.5       
 200 45 0.225 20.0 6 0.030 3.0 39 0.195 17.5 0 0.000 0.0
Cyclophosphamide 
7.5       
 50 20 0.400 34.0 6 0.120 12.0 14 0.280 24.0 0 0.000 0.0
Trend: 1.410 -0.465 1.410  
Probability: 0.079 0.679 0.079  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 01/19/1988    Harvest Time: 13 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: 3-Amino-9-ethylcarbazole HCl 
16         
 200 6 0.030 2.5 3 0.015 1.5 2 0.010 0.5 1 0.005 1.0 
30         
 200 5 0.025 2.5 3 0.015 1.5 2 0.010 1.0 0 0.000 0.0 
50         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Positive Control: Cyclophosphamide 
2.5       
 200 28 0.140 12.0 3 0.015 1.5 25 0.125 11.0 0 0.000 0.0
Cyclophosphamide 
7.5       
 50 17 0.340 34.0 3 0.060 6.0 14 0.280 28.0 0 0.000 0.0
Trend: 0.053 0.056 0.229  
Probability: 0.479 0.478 0.409