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Study Information
Study Attribute Value
CEBS Accession Number: 002-01425-0001-0000-5
Chemical Name: 3-Aminotriazole
CASRN: 61-82-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 462567_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 06/26/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1045 425 0.407 8.50 25.6 0.000
Test Chemical 3-Aminotriazole 
400         
 50 1044 431 0.413 8.62 25.6 1.509 
1300         
 50 1041 519 0.499 10.38 25.6 22.587 
4000         
 50 1031 541 0.525 10.82 25.6 29.023
Positive Control Mitomycin-C 
 0.0015    
 50 1046 743 0.710 14.86 25.6 74.656
Mitomycin-C 
 0.01      
 5 105 318 3.029 63.60 25.6 644.672
Trend: 4.678        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 07/31/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1043 463 0.444 9.26 25.7 0.000
Test Chemical 3-Aminotriazole 
4600         
 50 1043 678 0.650 13.56 25.7 46.436 
5000         
 50 1027 648 0.631 12.96 25.7 42.137 
5600         
 50 1031 670 0.650 13.40 25.7 46.393 
6000         
 0 0 0 0.000 0.00 25.7 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1036 652 0.629 13.04 25.7 41.772
Mitomycin-C 
 0.01      
 5 103 254 2.466 50.80 25.7 455.520
Trend: 5.454        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 07/31/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1040 467 0.449 9.34 25.7 0.000
Test Chemical 3-Aminotriazole 
5000         
 50 1042 480 0.461 9.60 25.7 2.586 
5600         
 50 1047 478 0.457 9.56 25.7 1.671 
6000         
 50 1026 499 0.486 9.98 25.7 8.310
Positive Control Cyclophosphamide 
 0.4       
 50 1035 723 0.699 14.46 25.7 55.566
Cyclophosphamide 
2         
 5 100 177 1.770 35.40 25.7 294.176
Trend: 1.071        
Probability: 0.142