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Study Information
Study Attribute Value
CEBS Accession Number: 002-01425-0002-0000-6
Chemical Name: 3-Aminotriazole
CASRN: 61-82-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 462567_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 08/15/1984    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 3 0.030 2.0 0 0.000 0.0 3 0.030 2.0 0 0.000 0.0
Medium 
0         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: 3-Aminotriazole 
5200         
 100 4 0.040 4.0 0 0.000 0.0 1 0.010 1.0 3 0.030 3.0 
5600         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0 
6000         
 100 3 0.030 3.0 0 0.000 0.0 3 0.030 3.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.15      
 100 13 0.130 8.0 4 0.040 3.0 9 0.090 6.0 0 0.000 0.0
Mitomycin-C 
 0.5       
 25 8 0.320 32.0 4 0.160 16.0 4 0.160 16.0 0 0.000 0.0
Trend: -0.015 -1.346 1.093  
Probability: 0.506 0.911 0.137  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 08/15/1984    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Medium 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 3-Aminotriazole 
5200         
 100 4 0.040 4.0 1 0.010 1.0 3 0.030 3.0 0 0.000 0.0 
5600         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0 
6000         
 100 2 0.020 1.0 0 0.000 0.0 1 0.010 1.0 1 0.010 1.0
Positive Control: Cyclophosphamide 
7.5       
 100 7 0.070 5.0 1 0.010 1.0 6 0.060 4.0 0 0.000 0.0
Cyclophosphamide 
37.5       
 25 12 0.480 36.0 2 0.080 8.0 10 0.400 28.0 0 0.000 0.0
Trend: 0.173 -0.454 0.373  
Probability: 0.431 0.675 0.355