Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01425-0007-0000-1 |
Chemical Name: | 3-Aminotriazole |
CASRN: | 61-82-5 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Mutagenicity |
NTP Study ID: | G13828 |
Study Result: | Negative |
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Water | 0 | 94 | 114 | 74 | 26 | 26 |
94 | 86 | 73 | 26 | ||||
Test Chemical | 3-Aminotriazole | 1966 | 112 | 137 | 106 | 31 | |
2458 | 94 | 103 | 130 | 46 | 43 | ||
108 | 113 | 129 | 40 | ||||
3072 | 96 | 101 | 83 | 29 | |||
3840 | 122r | 128 | 119 | 33 | |||
84 | 85 | 113 | 45 | ||||
4800 | 91 | 92 | 87 | 32 | |||
Positive Control | Ethyl Methane Sulfonate | 500 | 46 | 36 | 786 | 565 | 538* |
52 | 38 | 799 | 511 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Water | 0 | 77 | 99 | 76 | 33 | 28 |
75 | 101 | 50 | 22 | ||||
Test Chemical | 3-Aminotriazole | 1573 | 86 | 148 | 79 | 31 | 39 |
57 | 94 | 80 | 47 | ||||
1966 | 74 | 121 | 99 | 45 | 43 | ||
82 | 139 | 103 | 42 | ||||
2458 | 84 | 135 | 128 | 51 | 49* | ||
77 | 140 | 108 | 47 | ||||
3072 | 71 | 78 | 110 | 52 | 52* | ||
66 | 80 | 103 | 52 | ||||
3840 | 87 | 91 | 131 | 50 | 63* | ||
72 | 72 | 164 | 76 | ||||
6000 | 81 | 77 | 74 | 31 | |||
Positive Control | Ethyl Methane Sulfonate | 500 | 39 | 25 | 950 | 805 | 823* |
34 | 25 | 862 | 841 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Water | 0 | 83 | 95 | 98 | 39 | 27 |
85 | 112 | 71 | 28 | ||||
98 | 95 | 60 | 21 | ||||
85 | 98 | 53 | 21 | ||||
Test Chemical | 3-Aminotriazole | 1258 | 105 | 116 | 102 | 32 | 35 |
105 | 132 | 121 | 39 | ||||
1573 | 100 | 132 | 86 | 29 | 33 | ||
97 | 111 | 94 | 32 | ||||
113 | 143 | 124 | 37 | ||||
1966 | 75 | 86 | 88 | 39 | 33 | ||
112 | 137 | 121 | 36 | ||||
106 | 141 | 75 | 24 | ||||
2458 | 107 | 124 | 109 | 34 | 32 | ||
99 | 124 | 105 | 35 | ||||
106 | 125 | 87 | 27 | ||||
3072 | 120 | 138 | 95 | 26 | 30 | ||
115 | 141 | 79 | 23 | ||||
101 | 85 | 120 | 40 | ||||
3840 | 105 | 80 | 103 | 33 | 34 | ||
102 | 110 | 107 | 35 | ||||
100 | 125 | 108 | 36 | ||||
4800 | 108 | 122 | 82 | 25 | 31 | ||
109 | 110 | 129 | 39 | ||||
98 | 103 | 82 | 28 | ||||
6000 | 95 | 106 | 91 | 32 | 36 | ||
93 | 86 | 111 | 40 | ||||
Positive Control | Ethyl Methane Sulfonate | 500 | 58 | 54 | 805 | 467 | 476* |
58 | 48 | 934 | 532 | ||||
73 | 65 | 940 | 428 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Water | 0 | 99 | 69 | 123 | 41 | 48 |
99 | 103 | 187 | 63 | ||||
114 | 118 | 125 | 37 | ||||
106 | 110 | 160 | 50 | ||||
Test Chemical | 3-Aminotriazole | 1560 | 124r | 111 | 126 | 34 | |
128r | 104 | 198 | 52 | ||||
120 | 93 | 188 | 52 | ||||
1894 | 120 | 117 | 159 | 44 | 44 | ||
114 | 107 | 148 | 43 | ||||
110 | 109 | 149 | 45 | ||||
2300 | 201r | 169 | 183 | 30 | 37 | ||
100 | 105 | 114 | 38 | ||||
115 | 102 | 124 | 36 | ||||
2792 | 118 | 96 | 119 | 34 | 33 | ||
114# | 101 | 112.5 | 33 | ||||
3391 | 98 | 87 | 145 | 49 | 49 | ||
97 | 82 | 149 | 51 | ||||
111 | 105 | 158 | 47 | ||||
4117 | 106 | 94 | 148 | 47 | 43 | ||
112 | 101 | 137 | 41 | ||||
115 | 110 | 144 | 42 | ||||
5000 | 103 | 93 | 147 | 48 | 53 | ||
97 | 71 | 170 | 58 | ||||
Positive Control | Ethyl Methane Sulfonate | 500 | 59 | 35 | 1432 | 809 | 782* |
56 | 32 | 1376 | 826 | ||||
64 | 33 | 1358 | 709 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Water | 0 | 81 | 102 | 149 | 61 | 61 |
81 | 79 | 144 | 59 | ||||
88 | 111 | 143 | 54 | ||||
86 | 108 | 174 | 67 | ||||
Test Chemical | 3-Aminotriazole | 1048 | 68 | 79 | 139 | 68 | |
1311 | 83 | 92 | 184 | 74 | 65 | ||
90# | 105 | 150 | 56 | ||||
1638 | 87# | 84 | 186 | 71 | 62 | ||
87 | 85 | 162 | 62 | ||||
89 | 88 | 137 | 51 | ||||
2048 | 90 | 93 | 102 | 38 | 47 | ||
74# | 70 | 112.5 | 51 | ||||
102# | 111 | 160 | 52 | ||||
2560 | 85 | 85 | 148 | 58 | 65 | ||
69 | 65 | 144 | 70 | ||||
92# | 85 | 184.5 | 67 | ||||
3200 | 91 | 82 | 131 | 48 | 51 | ||
80 | 68 | 124 | 52 | ||||
81 | 75 | 130 | 53 | ||||
4000 | 74 | 56 | 113 | 51 | 57 | ||
81 | 60 | 168 | 69 | ||||
80 | 66 | 124 | 51 | ||||
5000 | 72# | 47 | 136.5 | 63 | 59 | ||
73 | 42 | 115 | 53 | ||||
84# | 51 | 153 | 61 | ||||
Positive Control | 3-Methylcholanthrene | 7 | 81 | 53 | 489 | 202 | 224* |
83 | 52 | 540 | 218 | ||||
62 | 43 | 467 | 252 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Water | 0 | 103 | 97 | 188 | 61 | 60 |
101 | 95 | 196 | 65 | ||||
105 | 99 | 163 | 52 | ||||
116 | 109 | 222 | 64 | ||||
Test Chemical | 3-Aminotriazole | 1048 | 103 | 100 | 137 | 44 | 48 |
125r | 112 | 149 | 40 | ||||
110 | 95 | 168 | 51 | ||||
1311 | 105 | 99 | 207 | 66 | 57 | ||
109 | 94 | 207 | 63 | ||||
108 | 94 | 132 | 41 | ||||
1638 | 104 | 90 | 174 | 56 | 60 | ||
104 | 90 | 179 | 58 | ||||
101 | 87 | 201 | 67 | ||||
2048 | 106 | 91 | 158 | 50 | 49 | ||
110 | 95 | 172 | 52 | ||||
100 | 91 | 139 | 47 | ||||
2560 | 102 | 88 | 162 | 53 | 52 | ||
100 | 76 | 137 | 46 | ||||
105 | 86 | 180 | 57 | ||||
3200 | 116 | 95 | 128 | 37 | 42 | ||
112 | 89 | 132 | 39 | ||||
101 | 77 | 146 | 48 | ||||
4000 | 117 | 95 | 138 | 39 | 45 | ||
105 | 85 | 169 | 53 | ||||
102 | 79 | 133 | 43 | ||||
5000 | 104 | 68 | 195 | 63 | 48 | ||
108 | 74 | 137 | 42 | ||||
116 | 79 | 139 | 40 | ||||
Positive Control | 3-Methylcholanthrene | 7 | 75 | 49 | 620 | 277 | 279* |
70 | 43 | 532 | 255 | ||||
78 | 47 | 720 | 306 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 71 | 106 | 113 | 53 | 56 |
65 | 94 | 115 | 59 | ||||
Test Chemical | 3-Aminotriazole | 1966 | 76 | 118 | 71 | 31 | 40 |
71 | 119 | 103 | 48 | ||||
2458 | 82 | 131 | 121 | 49 | 44 | ||
75 | 123 | 87 | 39 | ||||
3072 | 75 | 123 | 69 | 31 | 31 | ||
81 | 129 | 77 | 32 | ||||
3840 | 80 | 117 | 120 | 50 | 46 | ||
74 | 103 | 94 | 42 | ||||
4800 | 69 | 98 | 117 | 57 | 49 | ||
75 | 108 | 93 | 41 | ||||
6000 | 78 | 116 | 94 | 40 | 41 | ||
79 | 132 | 100 | 42 | ||||
Positive Control | 3-Methylcholanthrene | 5 | 44 | 29 | 379 | 290 | 270* |
46 | 31 | 345 | 250 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Water | 0 | 82 | 111 | 316 | 128 | 133 |
72# | 89 | 298 | 137 | ||||
Test Chemical | 3-Aminotriazole | 1573 | 94 | 115 | 108 | 38 | 44 |
91 | 113 | 137 | 50 | ||||
1966 | 103 | 126 | 105 | 34 | 39 | ||
99 | 121 | 128 | 43 | ||||
2458 | 86 | 100 | 106 | 41 | 42 | ||
94 | 109 | 122 | 43 | ||||
3072 | 103 | 119 | 135 | 44 | 44 | ||
92 | 106 | 121 | 44 | ||||
3840 | 96 | 114 | 122 | 43 | 47 | ||
90 | 107 | 137 | 51 | ||||
4800 | 92 | 101 | 134 | 48 | 58 | ||
78# | 86 | 158 | 68 | ||||
6000 | 82 | 84 | 124 | 51 | 46 | ||
96# | 105 | 119 | 42 | ||||
Positive Control | 3-Methylcholanthrene | 5 | 37 | 19 | 525 | 469 | 469* |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Water | 0 | 88 | 99 | 132 | 50 | 55 |
92 | 104 | 172 | 63 | ||||
82 | 97 | 127 | 52 | ||||
Test Chemical | 3-Aminotriazole | 839 | 111 | 126 | 140 | 42 | 46 |
109 | 113 | 161 | 49 | ||||
1048 | 103 | 127 | 112 | 36 | 38 | ||
107 | 110 | 125 | 39 | ||||
1311 | 104 | 122 | 127 | 41 | 38 | ||
98 | 111 | 104 | 35 | ||||
1638 | 103 | 118 | 154 | 50 | 44 | ||
103 | 104 | 118 | 38 | ||||
2048 | 124r | 148 | 165 | 44 | |||
102 | 103 | 161 | 53 | ||||
2560 | 96 | 110 | 116 | 40 | 45 | ||
90 | 94 | 137 | 51 | ||||
3200 | 157r | 164 | 187 | 40 | |||
99 | 105 | 129 | 43 | ||||
4000 | 120 | 124 | 137 | 38 | |||
160r | 159 | 185 | 39 | ||||
5000 | 114 | 123 | 108 | 32 | |||
Positive Control | 3-Methylcholanthrene | 5 | 58 | 29 | 610 | 350 | 334* |
57 | 26 | 559 | 329 | ||||
68 | 35 | 665 | 324 |
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination