Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01425-0008-0000-2 |
Chemical Name: | 3-Aminotriazole |
CASRN: | 61-82-5 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Mutagenicity |
NTP Study ID: | G60217 |
Study Result: | Negative |
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Water | 0 | 68 | 102 | 155 | 76 | 63 |
71 | 54 | 106 | 50 | ||||
Test Chemical | 3-Aminotriazole | 313 | 71 | 107 | 108 | 51 | 54 |
73 | 87 | 124 | 57 | ||||
625 | 83 | 108 | 158 | 63 | 68 | ||
81 | 119 | 177 | 73 | ||||
1250 | 73 | 89 | 119 | 54 | 52 | ||
64 | 101 | 96 | 50 | ||||
2500 | 71 | 94 | 105 | 49 | 61 | ||
76# | 107 | 165 | 72 | ||||
5000 | 81 | 99 | 163 | 67 | 67 | ||
73 | 90 | 146 | 67 | ||||
Positive Control | Ethyl Methane Sulfonate | 500 | 31 | 32 | 888 | 955 | 926* |
34 | 33 | 906 | 897 | ||||
Negative Control | Negative (Not Specified) | 0 | 92 | 123 | 155 | 56 | 48* |
92 | 121 | 110 | 40 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Water | 0 | 112 | 107 | 78 | 23 | 29 |
78# | 77 | 79.5 | 34 | ||||
Test Chemical | 3-Aminotriazole | 1250 | 86 | 89 | 66 | 26 | 26 |
92# | 96 | 70.5 | 25 | ||||
2500 | 104 | 92 | 60 | 19 | 26 | ||
83 | 89 | 81 | 33 | ||||
5000 | 105 | 79 | 118 | 38 | 37 | ||
98 | 87 | 106 | 36 | ||||
7500 | 107 | 84 | 128 | 40 | 37 | ||
115 | 86 | 119 | 35 | ||||
9999.9 | 95 | 59 | 130 | 46 | 40 | ||
99# | 72 | 101 | 34 | ||||
Positive Control | Ethyl Methane Sulfonate | 500 | 49 | 21 | 827 | 566 | 611* |
40 | 17 | 790 | 656 | ||||
Negative Control | Negative (Not Specified) | 0 | 114 | 110 | 74 | 22 | 20* |
111 | 107 | 63 | 19 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Water | 0 | 55 | 88 | 164 | 100 | 95 |
58 | 107 | 156 | 89 | ||||
Test Chemical | 3-Aminotriazole | 313 | 51 | 143 | 67 | 44 | 50 |
69 | 120 | 115 | 56 | ||||
625 | 70 | 163 | 94 | 45 | 57 | ||
57 | 133 | 120 | 70 | ||||
1250 | 52 | 115 | 99 | 64 | 57 | ||
55 | 118 | 85 | 51 | ||||
2500 | 54 | 139 | 97 | 60 | 57 | ||
44# | 98 | 72 | 55 | ||||
5000 | 61# | 126 | 78 | 43 | 41 | ||
62 | 148 | 73 | 39 | ||||
Positive Control | 3-Methylcholanthrene | 7 | 52# | 23 | 675 | 429 | 482* |
48 | 14 | 767 | 536 | ||||
Negative Control | Negative (Not Specified) | 0 | 63 | 102 | 214 | 113 | 103* |
63# | 104 | 175 | 93 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Water | 0 | 104 | 119 | 191 | 61 | 57 |
98 | 89 | 200 | 68 | ||||
97 | 91 | 155 | 53 | ||||
96 | 101 | 132 | 46 | ||||
Test Chemical | 3-Aminotriazole | 156 | 99 | 123 | 126 | 43 | 46 |
93 | 96 | 139 | 50 | ||||
313 | 81 | 97 | 111 | 46 | 45 | ||
92 | 102 | 119 | 43 | ||||
625 | 75 | 90 | 106 | 47 | 42 | ||
87 | 88 | 97 | 37 | ||||
1250 | 91 | 74 | 156 | 57 | 59 | ||
71# | 89 | 129 | 61 | ||||
2500 | 75 | 71 | 109 | 48 | 62 | ||
84 | 69 | 190 | 75 | ||||
5000 | 93 | 87 | 137 | 49 | 49 | ||
87 | 86 | 127 | 49 | ||||
Positive Control | 3-Methylcholanthrene | 7 | 68 | 36 | 609 | 297 | 283* |
75 | 27 | 606 | 269 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Water | 0 | 63 | 82 | 65 | 35 | 30 |
87 | 116 | 60 | 23 | ||||
84 | 119 | 66 | 26 | ||||
92 | 83 | 94 | 34 | ||||
Test Chemical | 3-Aminotriazole | 156 | 104 | 112 | 104 | 33 | 34 |
88 | 118 | 91 | 34 | ||||
313 | 113 | 133 | 46 | 14 | 21 | ||
96 | 109 | 82 | 29 | ||||
625 | 86 | 101 | 61 | 24 | 23 | ||
119 | 117 | 77 | 22 | ||||
1250 | 103 | 135 | 38 | 12 | |||
139r | 110 | 67 | 16 | ||||
2500 | 108 | 121 | 51 | 16 | 19 | ||
82 | 106 | 56 | 23 | ||||
5000 | 104 | 136 | 54 | 17 | 21 | ||
107 | 130 | 76 | 24 | ||||
Positive Control | 3-Methylcholanthrene | 7 | 70 | 48 | 415 | 197 | 168* |
80 | 51 | 360 | 150 | ||||
86 | 54 | 401 | 156 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Water | 0 | 74# | 43 | 144 | 65 | 52 |
64 | 141 | 76 | 40 | ||||
Test Chemical | 3-Aminotriazole | 1250 | 76 | 137 | 68 | 30 | 34 |
76 | 128 | 87 | 38 | ||||
2500 | 78 | 110 | 78 | 33 | 36 | ||
95 | 139 | 108 | 38 | ||||
5000 | 72 | 106 | 106 | 49 | 44 | ||
66# | 99 | 76.5 | 39 | ||||
7500 | 98 | 144 | 117 | 40 | 48 | ||
61 | 99 | 103 | 56 | ||||
9999.9 | 71 | 112 | 98 | 46 | 47 | ||
73 | 20 | 105 | 48 | ||||
Positive Control | 3-Methylcholanthrene | 5 | 47 | 25 | 543 | 382 | 340* |
55 | 47 | 491 | 297 | ||||
Negative Control | Negative (Not Specified) | 0 | 66 | 80 | 153 | 77 | 63* |
86 | 136 | 125 | 48 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Water | 0 | 102 | 107 | 203 | 66 | 80 |
97 | 110 | 216 | 75 | ||||
84 | 97 | 213 | 85 | ||||
75 | 86 | 216 | 96 | ||||
Test Chemical | 3-Aminotriazole | 156 | 103 | 142 | 172 | 56 | 62 |
98 | 114 | 199 | 68 | ||||
313 | 85 | 127 | 146 | 57 | 52 | ||
93 | 165 | 130 | 47 | ||||
625 | 96 | 125 | 174 | 61 | 53 | ||
111 | 148 | 149 | 45 | ||||
1250 | 97 | 172 | 121 | 42 | 43 | ||
107 | 168 | 139 | 43 | ||||
2500 | 95 | 165 | 150 | 53 | 56 | ||
90 | 142 | 157 | 58 | ||||
5000 | 90 | 159 | 157 | 58 | 59 | ||
89 | 113 | 157 | 59 | ||||
Positive Control | 3-Methylcholanthrene | 5 | 35 | 8 | 568 | 546 | 552* |
33 | 10 | 553 | 559 |
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination