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Study Information
Study Attribute Value
CEBS Accession Number: 002-01432-0014-0000-7
Chemical Name: 3-Chloro-2-methylpropene
CASRN: 563-47-3
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 223649_SCE
Study Result: Positive


Table Instructions and Notes:

Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.


Summary of Sister Chromatid Exchange Data (Trial 1)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 07/15/86 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 5.25 ± 0.283
Test Chemical 3-Chloro-2-methylpropene 
75         
 4 4.36 ± 0.236
  
150         
 4 6.20 ± 0.589
  
300         
 4 7.74 ± 0.676
Positive Control Dimethylbenzanthracene 
2.5       
 4 9.75 ± 0.998


Summary of Sister Chromatid Exchange Data (Trial 2)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 07/23/87 42 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  42 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 5.10 ± 0.425
Test Chemical 3-Chloro-2-methylpropene 
75         
 4 4.92 ± 0.138
  
150         
 4 5.62 ± 0.358
  
300         
 3 4.55 ± 0.597
Positive Control Dimethylbenzanthracene 
2.5       
 4 12.73 ± 0.531


Summary of Sister Chromatid Exchange Data (Trial 3)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 10/28/87 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 5.15 ± 0.261
Test Chemical 3-Chloro-2-methylpropene 
225         
 4 5.07 ± 0.355
  
300         
 4 7.25 ± 0.295
  
375         
 3 10.45 ± 1.460
Positive Control Dimethylbenzanthracene 
2.5       
 4 8.82 ± 0.525


Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed