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Study Information
Study Attribute Value
CEBS Accession Number: 002-01432-0015-0000-8
Chemical Name: 3-Chloro-2-methylpropene
CASRN: 563-47-3
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 223649_CA
Study Result: Positive

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 07/30/86 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.0201
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 7.50 ± 1.18 0.0001
Test Chemical 3-Chloro-2-methylpropene 
75         
 8 1.75 ± 0.59 0.5000
  
150         
 8 2.00 ± 0.38 0.3972
  
300         
 8 3.75 ± 0.88 0.0419
Vehicle Control No Stressor 
 0         
 8 1.75 ± 0.80 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 01/27/87 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.9374
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Mitomycin-C 
1         
 8 5.75 ± 1.94 0.0058
Test Chemical 3-Chloro-2-methylpropene 
225         
 8 0.75 ± 0.37 0.9595
  
300         
 8 1.25 ± 0.53 0.8596
Vehicle Control No Stressor 
 0         
 8 2.25 ± 0.45 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 11/11/87 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.0001
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 24.00 ± 2.24 0.0000
Test Chemical 3-Chloro-2-methylpropene 
150         
 8 2.00 ± 1.13 0.0281
  
300         
 8 2.00 ± 1.00 0.0281
  
600         
 8 4.50 ± 0.82 0.0001
Vehicle Control No Stressor 
 0         
 8 0.50 ± 0.33 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed