Genetic Toxicology - Rodent Cytogenetics

Study Information
Study Attribute	Value
CEBS Accession Number:	002-01432-0016-0000-9
Chemical Name:	3-Chloro-2-methylpropene
CASRN:	563-47-3
NTP Study Type:	Genetic Toxicology - Rodent Cytogenetics
NTP Study ID:	876278_SCE
Study Result:	Negative (Nonstandard Protocol)

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Table Instructions and Notes:

Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.

Summary of Sister Chromatid Exchange Data (Trial 1)
Test Type	Start Date	Sample Time (h)	Species	Sex	Strain	Tissue	Protocol	Trend Test P
SCE	07/29/86	23	Mouse	Male	B6C3F1	Bone Marrow	IP/IJ x 1, 23 hour

		Dose (mg/kg)	n	SCE / Cell (Mean ± SEM)
Vehicle Control	Corn Oil	0	4	4.66 ± 0.478
Test Chemical	3-Chloro-2-methylpropene	62.5	4	4.49 ± 0.391
		125	4	5.04 ± 0.212
		250	4	4.97 ± 0.454
Positive Control	Dimethylbenzanthracene	2.5	4	8.74 ± 0.470

Summary of Sister Chromatid Exchange Data (Trial 2)
Test Type	Start Date	Sample Time (h)	Species	Sex	Strain	Tissue	Protocol	Trend Test P
SCE	02/22/88	42	Mouse	Male	B6C3F1	Bone Marrow	IP/IJ x 1, 42 hour

		Dose (mg/kg)	n	SCE / Cell (Mean ± SEM)
Vehicle Control	Corn Oil	0	4	6.21 ± 1.911
Test Chemical	3-Chloro-2-methylpropene	62.5	4	4.47 ± 1.486
		125	4	3.42 ± 0.231
		250	4	3.65 ± 0.504
Positive Control	Dimethylbenzanthracene	2.5	4	7.97 ± 1.391

Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed