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Study Information
Study Attribute Value
CEBS Accession Number: 002-01432-0016-0000-9
Chemical Name: 3-Chloro-2-methylpropene
CASRN: 563-47-3
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 876278_SCE
Study Result: Negative (Nonstandard Protocol)


Table Instructions and Notes:

Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.


Summary of Sister Chromatid Exchange Data (Trial 1)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 07/29/86 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 4.66 ± 0.478
Test Chemical 3-Chloro-2-methylpropene 
62.5       
 4 4.49 ± 0.391
  
125         
 4 5.04 ± 0.212
  
250         
 4 4.97 ± 0.454
Positive Control Dimethylbenzanthracene 
2.5       
 4 8.74 ± 0.470


Summary of Sister Chromatid Exchange Data (Trial 2)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 02/22/88 42 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  42 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 6.21 ± 1.911
Test Chemical 3-Chloro-2-methylpropene 
62.5       
 4 4.47 ± 1.486
  
125         
 4 3.42 ± 0.231
  
250         
 4 3.65 ± 0.504
Positive Control Dimethylbenzanthracene 
2.5       
 4 7.97 ± 1.391


Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed