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Study Information
Study Attribute Value
CEBS Accession Number: 002-01432-0017-0000-0
Chemical Name: 3-Chloro-2-methylpropene
CASRN: 563-47-3
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 876278_CA
Study Result: Negative

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 07/31/86 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.1328
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 12.50 ± 2.38 0.0000
Test Chemical 3-Chloro-2-methylpropene 
62.5       
 8 3.25 ± 1.06 0.0058
  
125         
 8 2.00 ± 0.76 0.0645
  
250         
 8 2.50 ± 1.05 0.0251
Vehicle Control No Stressor 
 0         
 8 0.75 ± 0.53 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 03/21/88 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.3962
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 28.25 ± 3.47 0.0000
Test Chemical 3-Chloro-2-methylpropene 
62.5       
 8 5.25 ± 1.41 0.2531
  
125         
 8 3.75 ± 1.10 0.6409
  
250         
 8 5.00 ± 1.60 0.3068
Vehicle Control No Stressor 
 0         
 8 4.25 ± 1.28 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 12/02/91 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.7464
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
50         
 7 7.71 ± 2.16 0.0000
Test Chemical 3-Chloro-2-methylpropene 
62.5       
 8 2.25 ± 0.59 0.0810
  
125         
 8 0.50 ± 0.33 0.7938
  
250         
 8 1.00 ± 0.53 0.5000
Vehicle Control No Stressor 
 0         
 8 1.00 ± 0.53 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed