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Study Information
Study Attribute Value
CEBS Accession Number: 002-01435-0001-0000-6
Chemical Name: 3-Chloro-p-toluidine
CASRN: 95-74-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 966841_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 12/15/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1043 426 0.408 8.52 26.0 0.000
Test Chemical 3-Chloro-p-toluidine 
5         
 50 1046 438 0.419 8.76 26.0 2.522 
16         
 50 1048 451 0.430 9.02 26.0 5.363 
50         
 50 1045 434 0.415 8.68 26.0 1.683
Positive Control Mitomycin-C 
 0.005     
 25 523 732 1.400 29.28 26.0 242.676
Trend: 0.363        
Probability: 0.358        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 12/15/1982    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 451 0.430 9.02 26.0 0.000
Test Chemical 3-Chloro-p-toluidine 
50         
 50 1048 502 0.479 10.04 26.0 11.521 
160         
 50 1046 550 0.526 11.00 26.0 22.418 
500         
 50 1046 554 0.530 11.08 26.0 23.308
Positive Control Cyclophosphamide 
1         
 50 1048 1117 1.066 22.34 26.0 148.144
Trend: 3.591        
Probability: 0.000