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Study Information
Study Attribute Value
CEBS Accession Number: 002-01435-0002-0000-7
Chemical Name: 3-Chloro-p-toluidine
CASRN: 95-74-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 966841_CA
Study Result: Equivocal

Study Result: Equivocal
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 12/15/1982    Harvest Time: 14 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: 3-Chloro-p-toluidine 
16         
 100 7 0.070 6.0 3 0.030 3.0 4 0.040 4.0 0 0.000 0.0 
50         
 100 9 0.090 9.0 3 0.030 3.0 6 0.060 6.0 0 0.000 0.0 
160         
 100 10 0.100 10.0 4 0.040 4.0 6 0.060 6.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.15      
 50 21 0.420 34.0 7 0.140 14.0 14 0.280 24.0 0 0.000 0.0
Trend: 2.405 1.719 1.508  
Probability: 0.008 0.043 0.066  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 12/15/1982    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 4 0.040 4.0 1 0.010 1.0 3 0.030 3.0 0 0.000 0.0
Test Chemical: 3-Chloro-p-toluidine 
50         
 100 7 0.070 5.0 2 0.020 2.0 5 0.050 3.0 0 0.000 0.0 
160         
 100 8 0.080 8.0 2 0.020 2.0 6 0.060 6.0 0 0.000 0.0 
500         
 100 9 0.090 8.0 3 0.030 3.0 6 0.060 6.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
15         
 50 14 0.280 26.0 3 0.060 6.0 11 0.220 20.0 0 0.000 0.0
Trend: 1.388 0.957 1.296  
Probability: 0.083 0.169 0.097