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Study Information
Study Attribute Value
CEBS Accession Number: 002-01436-0001-0000-7
Chemical Name: 3-Chloromethylpyridine hydrochloride
CASRN: 6959-48-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 240038_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 11/17/1982    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1042 461 0.442 9.22 25.5 0.000
Test Chemical 3-Chloromethylpyridine hydrochloride 
 0.5       
 50 1029 639 0.621 12.78 25.5 40.363 
1.67      
 50 1043 829 0.795 16.58 25.5 79.654 
5         
 50 1048 927 0.885 18.54 25.5 99.933 
16.7       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1035 656 0.634 13.12 25.5 43.262
Mitomycin-C 
 0.01      
 5 104 247 2.375 49.40 25.5 436.822
Trend: 13.113        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 11/17/1982    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1047 461 0.440 9.22 25.5 0.000
Test Chemical 3-Chloromethylpyridine hydrochloride 
5         
 50 1045 501 0.479 10.02 25.5 8.885 
16.7       
 50 1040 656 0.631 13.12 25.5 43.257 
50         
 50 1036 673 0.650 13.46 25.5 47.537 
167         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.3       
 50 1042 620 0.595 12.40 25.5 35.136
Cyclophosphamide 
2         
 5 104 135 1.298 27.00 25.5 194.813
Trend: 7.622        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 01/05/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1046 442 0.423 8.84 25.5 0.000
Test Chemical 3-Chloromethylpyridine hydrochloride 
40         
 50 1045 704 0.674 14.08 25.5 59.428 
60         
 50 1040 876 0.842 17.52 25.5 99.333 
80         
 50 1037 937 0.904 18.74 34.0 113.831
Positive Control Cyclophosphamide 
 0.3       
 50 1043 651 0.624 13.02 25.5 47.709
Cyclophosphamide 
2         
 5 105 190 1.810 38.00 25.5 328.227
Trend: 13.931        
Probability: 0.000