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Study Information
Study Attribute Value
CEBS Accession Number: 002-01436-0002-0000-8
Chemical Name: 3-Chloromethylpyridine hydrochloride
CASRN: 6959-48-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 240038_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #:1   Activation: No Activation    Date: 12/21/1982    Harvest Time: 10.5 hour(s)   Trial Call: Weakly Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: 3-Chloromethylpyridine hydrochloride 
15         
 100 3 0.030 3.0 0 0.000 0.0 3 0.030 3.0 0 0.000 0.0 
20         
 100 3 0.030 3.0 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0 
25         
 100 14 0.140 12.0 1 0.010 1.0 13 0.130 11.0 0 0.000 0.0
Positive Control: Mitomycin-C 
1         
 50 22 0.440 28.0 7 0.140 12.0 15 0.300 20.0 0 0.000 0.0
Trend: 2.985 1.359 2.644  
Probability: 0.001 0.087 0.004  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 12/21/1982    Harvest Time: 10.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 3 0.030 3.0 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 9 0.090 5.0 0 0.000 0.0 9 0.090 5.0 0 0.000 0.0
Test Chemical: 3-Chloromethylpyridine hydrochloride 
50         
 100 14 0.140 14.0 3 0.030 3.0 11 0.110 11.0 0 0.000 0.0 
75         
 100 20 0.200 16.0 7 0.070 5.0 13 0.130 11.0 0 0.000 0.0 
100         
 100 30 0.300 20.0 7 0.070 7.0 23 0.230 16.0 0 0.000 0.0 
125         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
50         
 50 16 0.320 22.0 6 0.120 12.0 10 0.200 12.0 0 0.000 0.0
Trend: 3.016 2.697 2.328  
Probability: 0.001 0.003 0.010