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Study Information
Study Attribute Value
CEBS Accession Number: 002-01436-0014-0000-1
Chemical Name: 3-Chloromethylpyridine hydrochloride
CASRN: 6959-48-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID: G35871
Study Result: Positive


Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 89 103 82 31 32
    84 97 83 33
Test Chemical 3-Chloromethylpyridine hydrochloride 
12.6       
 90 88 149 55 74*
    80 83 224 93
  
15.7       
 102 92 217 71 70*
    90 85 184 68
  
19.7       
 88 75 207 79 86*
    80 72 221 93
  
24.6       
 94 71 213 76 96*
    79 62 274 116
  
30.7       
 91 48 235 86 85*
    79 49 199 84
  
38.4       
 70 20 250 118 111*
    70 22 219 104
  
48         
 39 4 146 124 133*
    52 7 222 142
Positive Control Ethyl Methane Sulfonate 
500         
 58 39 725 420 420*

Nonactivation Trial: 2 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Water 
 0         
 94 106 104 37 38
    83 76 102 41
    91 118 98 36
Test Chemical 3-Chloromethylpyridine hydrochloride 
19.7       
 99 68 333 112 108*
    94 66 292 104
  
24.6       
 107 75 355 111 111*
    94 71 312 111
  
30.7       
 88 55 442 168 163*
    90 52 427 159
  
38.4       
 81 19 604 250 226*
    93 31 565 203
  
48         
 46 6 593 430 453*
    51 6 723 476
Positive Control Ethyl Methane Sulfonate 
500         
 48 31 1234 860 829*
    57 35 1346 792
    55 44 1378 835

Induced S9 Trial: 1 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Water 
 0         
 97 107 94 32 37
    96 73 130 45
    104 131 102 33
    89 89 101 38
Test Chemical 3-Chloromethylpyridine hydrochloride 
7.9       
 168r 223 129 26 44
    100 120 123 41
    56 70 78 47
  
9.8       
 96 101 90 31 32
    110 140 109 33
    109 133 100 31
  
12.3       
 72 77 147 68 52
    105 108 145 46
    94 110 116 41
  
15.4       
 117 111 149 42 43
    100 98 131 44
    135r 130 168 42
  
19.2       
 106 87 131 41 44
    116 92 137 39
    95 83 148 52
  
24         
 92 54 211 76 73*
    83 56 165 67
    84 58 191 76
  
30         
 84 36 341 135 151*
    69 35 297 143
    64 31 335 174
Positive Control 3-Methylcholanthrene 
5         
 90 83 510 188 252*
    57 37 525 310
    73 70 563 258

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination