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Study Information
Study Attribute Value
CEBS Accession Number: 002-01444-0001-0000-6
Chemical Name: 3-Iodo-1,2-propanediol
CASRN: 554-10-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 817306_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Weakly Positive 

Trial #: 1    Activation: No Activation    Date: 03/07/1989    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1045 401 0.384 8.02 26.0 0.000
Negative (Not Specified) 
0         
 50 1041 369 0.354 7.38 26.0 -7.626
Test Chemical 3-Iodo-1,2-propanediol 
17         
 50 1048 491 0.469 9.82 26.0 22.093 
50         
 50 1047 708 0.676 14.16 26.0 76.221 
167         
 50 1046 1464 1.400 29.28 26.0 264.738 
500         
 50 1049 2671 2.546 53.42 26.0 563.545 
1667         
 0 0 0 0.000 0.00 0.0 N/A 
5000         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1045 627 0.600 12.54 26.0 56.359
Mitomycin-C 
 0.005     
 10 210 268 1.276 26.80 26.0 232.573
Trend: 51.497        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 04/17/1989    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1049 394 0.376 7.88 26.0 -1.839
Water 
0         
 50 1048 401 0.383 8.02 26.0 0.000
Test Chemical 3-Iodo-1,2-propanediol 
17         
 50 1049 701 0.668 14.02 26.0 74.646 
50         
 50 1047 936 0.894 18.72 26.0 133.639 
167         
 50 1045 1692 1.619 33.84 26.0 323.156 
500         
 50 1053 2853 2.709 57.06 26.0 608.093 
1667         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1050 640 0.610 12.80 26.0 59.297
Mitomycin-C 
 0.005     
 10 210 342 1.629 34.20 26.0 325.622
Trend: 51.323        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 03/07/1989    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1052 396 0.376 7.92 26.0 -4.578
Water 
0         
 50 1052 415 0.394 8.30 26.0 0.000
Test Chemical 3-Iodo-1,2-propanediol 
167         
 50 1048 454 0.433 9.08 26.0 9.815 
500         
 50 1053 472 0.448 9.44 26.0 13.627 
1667         
 50 1049 448 0.427 8.96 26.0 8.261 
5000         
 50 1050 646 0.615 12.92 26.0 55.959
Positive Control Cyclophosphamide 
 0.125     
 50 1053 555 0.527 11.10 26.0 33.608
Cyclophosphamide 
 0.5       
 10 211 176 0.834 17.60 26.0 111.445
Trend: 6.524        
Probability: 0.000