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Study Information
Study Attribute Value
CEBS Accession Number: 002-01449-0001-0000-1
Chemical Name: 3-Methylcholanthrene
CASRN: 56-49-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 722375_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 12/19/1980    Trial Call: Positive   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide
0         
50 1048 403 0.385 8.06 26.0 0.000
Test Chemical 3-Methylcholanthrene
 0.5       
50 1049 456 0.435 9.12 26.0 13.043
1         
50 1047 446 0.426 8.92 26.0 10.776
5         
50 1047 495 0.473 9.90 26.0 22.946
10         
50 1047 544 0.520 10.88 26.0 35.117
50         
50 1048 603 0.575 12.06 26.0 49.628
Positive Control Triethylenemelamine
 0.025     
50 1047 2134 2.038 42.68 26.0 430.034
Trend: 7.181        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 12/19/1980    Trial Call: Positive   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide
0         
50 1047 426 0.407 8.52 26.0 0.000
Test Chemical 3-Methylcholanthrene
 0.5       
50 1049 499 0.476 9.98 26.0 16.913
1         
50 1048 567 0.541 11.34 26.0 32.972
5         
50 1047 609 0.582 12.18 26.0 42.958
10         
50 1049 699 0.666 13.98 26.0 63.772
50         
50 1050 741 0.706 14.82 26.0 73.447
Positive Control Cyclophosphamide
1.5       
50 1048 1775 1.694 35.50 26.0 316.269
Trend: 10.713        
Probability: 0.000