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Study Information
Study Attribute Value
CEBS Accession Number: 002-01449-0001-0000-1
Chemical Name: 3-Methylcholanthrene
CASRN: 56-49-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 722375_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 12/19/1980    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1048 403 0.385 8.06 26.0 0.000
Test Chemical 3-Methylcholanthrene 
 0.5       
 50 1049 456 0.435 9.12 26.0 13.043 
1         
 50 1047 446 0.426 8.92 26.0 10.776 
5         
 50 1047 495 0.473 9.90 26.0 22.946 
10         
 50 1047 544 0.520 10.88 26.0 35.117 
50         
 50 1048 603 0.575 12.06 26.0 49.628
Positive Control Triethylenemelamine 
 0.025     
 50 1047 2134 2.038 42.68 26.0 430.034
Trend: 7.181        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 12/19/1980    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1047 426 0.407 8.52 26.0 0.000
Test Chemical 3-Methylcholanthrene 
 0.5       
 50 1049 499 0.476 9.98 26.0 16.913 
1         
 50 1048 567 0.541 11.34 26.0 32.972 
5         
 50 1047 609 0.582 12.18 26.0 42.958 
10         
 50 1049 699 0.666 13.98 26.0 63.772 
50         
 50 1050 741 0.706 14.82 26.0 73.447
Positive Control Cyclophosphamide 
1.5       
 50 1048 1775 1.694 35.50 26.0 316.269
Trend: 10.713        
Probability: 0.000