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Study Information
Study Attribute Value
CEBS Accession Number: 002-01449-0002-0000-2
Chemical Name: 3-Methylcholanthrene
CASRN: 56-49-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 722375_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 12/19/1980    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: 3-Methylcholanthrene 
 0.5       
 100 6 0.060 3.0 1 0.010 1.0 5 0.050 2.0 0 0.000 0.0 
1         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 
5         
 100 5 0.050 5.0 0 0.000 0.0 5 0.050 5.0 0 0.000 0.0 
10         
 100 8 0.080 8.0 1 0.010 1.0 7 0.070 7.0 0 0.000 0.0 
50         
 100 9 0.090 7.0 2 0.020 2.0 7 0.070 5.0 0 0.000 0.0
Positive Control: Triethylenemelamine 
 0.25      
 100 44 0.440 36.0 14 0.140 13.0 30 0.300 26.0 0 0.000 0.0
Trend: 2.475 1.168 2.165  
Probability: 0.007 0.121 0.015  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 12/19/1980    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: 3-Methylcholanthrene 
 0.5       
 100 6 0.060 4.0 3 0.030 2.0 3 0.030 3.0 0 0.000 0.0 
1         
 100 4 0.040 3.0 1 0.010 1.0 3 0.030 2.0 0 0.000 0.0 
5         
 100 9 0.090 8.0 4 0.040 4.0 5 0.050 5.0 0 0.000 0.0 
10         
 100 7 0.070 7.0 4 0.040 4.0 3 0.030 3.0 0 0.000 0.0 
50         
 100 7 0.070 5.0 5 0.050 4.0 2 0.020 2.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
25         
 100 90 0.900 53.0 33 0.330 30.0 57 0.570 37.0 0 0.000 0.0
Trend: 1.629 1.831 0.624  
Probability: 0.052 0.034 0.266