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Study Information
Study Attribute Value
CEBS Accession Number: 002-01449-0003-0000-3
Chemical Name: 3-Methylcholanthrene
CASRN: 56-49-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 920375_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 10/26/1980    Trial Call: Positive   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide
0         
50 1036 311 0.300 6.22 26.8 0.000
Negative (Not Specified)
0         
50 1032 311 0.301 6.22 26.8 0.388
Test Chemical 3-Methylcholanthrene
 0.01      
50 1033 346 0.335 6.92 26.8 11.577
1         
50 1025 371 0.362 7.42 26.8 20.573
100         
50 1023 434 0.424 8.68 26.8 41.323
Positive Control Triethylenemelamine
 0.015     
50 1026 1140 1.111 22.80 26.8 270.132
Trend: 4.803        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 10/18/1980    Trial Call: Positive   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified)
0         
50 1044 408 0.391 8.16 26.8 33.880
Dimethyl Sulfoxide
0         
50 1038 303 0.292 6.06 26.8 0.000
Test Chemical 3-Methylcholanthrene
 0.01      
50 1041 509 0.489 10.18 26.8 67.503
1         
50 1037 500 0.482 10.00 26.8 65.176
100         
50 1029 439 0.427 8.78 26.8 46.152
Positive Control Cyclophosphamide
1.5       
50 1042 1800 1.727 36.00 26.8 491.779
Trend: 4.409        
Probability: 0.000