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Study Information
Study Attribute Value
CEBS Accession Number: 002-01449-0003-0000-3
Chemical Name: 3-Methylcholanthrene
CASRN: 56-49-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 920375_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 10/26/1980    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1036 311 0.300 6.22 26.8 0.000
Negative (Not Specified) 
0         
 50 1032 311 0.301 6.22 26.8 0.388
Test Chemical 3-Methylcholanthrene 
 0.01      
 50 1033 346 0.335 6.92 26.8 11.577 
1         
 50 1025 371 0.362 7.42 26.8 20.573 
100         
 50 1023 434 0.424 8.68 26.8 41.323
Positive Control Triethylenemelamine 
 0.015     
 50 1026 1140 1.111 22.80 26.8 270.132
Trend: 4.803        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 10/18/1980    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1044 408 0.391 8.16 26.8 33.880
Dimethyl Sulfoxide 
0         
 50 1038 303 0.292 6.06 26.8 0.000
Test Chemical 3-Methylcholanthrene 
 0.01      
 50 1041 509 0.489 10.18 26.8 67.503 
1         
 50 1037 500 0.482 10.00 26.8 65.176 
100         
 50 1029 439 0.427 8.78 26.8 46.152
Positive Control Cyclophosphamide 
1.5       
 50 1042 1800 1.727 36.00 26.8 491.779
Trend: 4.409        
Probability: 0.000