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Study Information
Study Attribute Value
CEBS Accession Number: 002-01449-0004-0000-4
Chemical Name: 3-Methylcholanthrene
CASRN: 56-49-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 920375_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 12/02/1980    Harvest Time: 11 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: 3-Methylcholanthrene 
 0.01      
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
1         
 100 2 0.020 2.0 0 0.000 0.0 0 0.000 0.0 2 0.020 2.0 
100         
 79 1 0.013 1.0 1 0.013 1.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Triethylenemelamine 
 0.25      
 100 82 0.820 49.0 26 0.260 20.0 55 0.550 36.0 1 0.010 1.0
Trend: 0.474 1.292 -1.302  
Probability: 0.318 0.098 0.904  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 10/30/1980    Harvest Time: 10 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: 3-Methylcholanthrene 
 0.01      
 100 5 0.050 5.0 0 0.000 0.0 5 0.050 5.0 0 0.000 0.0 
1         
 100 4 0.040 4.0 1 0.010 1.0 3 0.030 3.0 0 0.000 0.0 
100         
 100 8 0.080 7.0 2 0.020 1.0 6 0.060 5.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
25         
 100 54 0.540 37.0 21 0.210 17.0 32 0.320 25.0 1 0.010 1.0
Trend: 1.884 1.268 1.217  
Probability: 0.030 0.102 0.112