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Study Information
Study Attribute Value
CEBS Accession Number: 002-01451-0001-0000-4
Chemical Name: 3-Nitro-p-acetophenetide
CASRN: 1777-84-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 320412_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 04/15/1987    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1028 475 0.462 9.50 25.5 0.000
Test Chemical 3-Nitro-p-acetophenetide 
16.7       
 50 1038 423 0.408 8.46 25.5 -11.805 
50         
 50 1027 497 0.484 9.94 25.5 4.733 
166.7       
 50 1032 543 0.526 10.86 25.5 13.873 
500         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1014 613 0.605 12.26 25.5 30.834
Mitomycin-C 
 0.01      
 5 104 197 1.894 39.40 25.5 309.951
Trend: 2.830        
Probability: 0.002        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 04/15/1987    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1030 461 0.448 9.22 25.5 0.000
Test Chemical 3-Nitro-p-acetophenetide 
50         
 50 1030 413 0.401 8.26 25.5 -10.412 
166.7       
 50 1034 487 0.471 9.74 25.5 5.231 
500         
 50 1040 472 0.454 9.44 25.5 1.402
Positive Control Cyclophosphamide 
 0.4       
 50 1033 657 0.636 13.14 25.5 42.102
Cyclophosphamide 
2         
 5 103 193 1.874 38.60 25.5 318.655
Trend: 0.982        
Probability: 0.163