U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Study Information
Study Attribute Value
CEBS Accession Number: 002-01451-0002-0000-5
Chemical Name: 3-Nitro-p-acetophenetide
CASRN: 1777-84-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 320412_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 06/17/1987    Harvest Time: 20.2 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0
Test Chemical: 3-Nitro-p-acetophenetide 
250         
 200 4 0.020 2.0 2 0.010 1.0 2 0.010 1.0 0 0.000 0.0 
375         
 200 8 0.040 3.5 2 0.010 1.0 6 0.030 3.0 0 0.000 0.0 
500         
 200 7 0.035 3.0 1 0.005 0.5 6 0.030 2.5 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.05      
 200 57 0.285 24.0 33 0.165 15.5 24 0.120 11.0 0 0.000 0.0
Mitomycin-C 
 0.08      
 25 17 0.680 52.0 5 0.200 20.0 12 0.480 36.0 0 0.000 0.0
Trend: 1.972 0.031 2.446  
Probability: 0.024 0.488 0.007  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 06/16/1987    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 6 0.030 3.0 3 0.015 1.5 3 0.015 1.5 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 6 0.030 2.5 2 0.010 1.0 4 0.020 1.5 0 0.000 0.0
Test Chemical: 3-Nitro-p-acetophenetide 
250         
 200 11 0.055 4.0 3 0.015 1.5 8 0.040 2.5 0 0.000 0.0 
375         
 200 9 0.045 4.0 4 0.020 1.5 4 0.020 2.0 1 0.005 0.5 
500         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
7.5       
 200 19 0.095 9.0 8 0.040 4.0 11 0.055 5.5 0 0.000 0.0
Cyclophosphamide 
37.5       
 25 8 0.320 28.0 3 0.120 12.0 5 0.200 16.0 0 0.000 0.0
Trend: -0.765 -0.883 -0.453  
Probability: 0.778 0.811 0.675