Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01451-0002-0000-5 |
Chemical Name: | 3-Nitro-p-acetophenetide |
CASRN: | 1777-84-0 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 320412_CA |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 200 | 2 | 0.010 | 1.0 | 1 | 0.005 | 0.5 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 | 200 | 1 | 0.005 | 0.5 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | 3-Nitro-p-acetophenetide | 250 | 200 | 4 | 0.020 | 2.0 | 2 | 0.010 | 1.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
375 | 200 | 8 | 0.040 | 3.5 | 2 | 0.010 | 1.0 | 6 | 0.030 | 3.0 | 0 | 0.000 | 0.0 | ||
500 | 200 | 7 | 0.035 | 3.0 | 1 | 0.005 | 0.5 | 6 | 0.030 | 2.5 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.05 | 200 | 57 | 0.285 | 24.0 | 33 | 0.165 | 15.5 | 24 | 0.120 | 11.0 | 0 | 0.000 | 0.0 |
Mitomycin-C | 0.08 | 25 | 17 | 0.680 | 52.0 | 5 | 0.200 | 20.0 | 12 | 0.480 | 36.0 | 0 | 0.000 | 0.0 | |
Trend: | 1.972 | 0.031 | 2.446 | ||||||||||||
Probability: | 0.024 | 0.488 | 0.007 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 200 | 6 | 0.030 | 3.0 | 3 | 0.015 | 1.5 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 | 200 | 6 | 0.030 | 2.5 | 2 | 0.010 | 1.0 | 4 | 0.020 | 1.5 | 0 | 0.000 | 0.0 | |
Test Chemical: | 3-Nitro-p-acetophenetide | 250 | 200 | 11 | 0.055 | 4.0 | 3 | 0.015 | 1.5 | 8 | 0.040 | 2.5 | 0 | 0.000 | 0.0 |
375 | 200 | 9 | 0.045 | 4.0 | 4 | 0.020 | 1.5 | 4 | 0.020 | 2.0 | 1 | 0.005 | 0.5 | ||
500 | 200 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 7.5 | 200 | 19 | 0.095 | 9.0 | 8 | 0.040 | 4.0 | 11 | 0.055 | 5.5 | 0 | 0.000 | 0.0 |
Cyclophosphamide | 37.5 | 25 | 8 | 0.320 | 28.0 | 3 | 0.120 | 12.0 | 5 | 0.200 | 16.0 | 0 | 0.000 | 0.0 | |
Trend: | -0.765 | -0.883 | -0.453 | ||||||||||||
Probability: | 0.778 | 0.811 | 0.675 |