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Study Information
Study Attribute Value
CEBS Accession Number: 002-01452-0001-0000-5
Chemical Name: 3-Nitropropionic acid
CASRN: 504-88-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 892866_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Weakly Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 09/11/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1043 379 0.363 7.58 26.0 -7.197
Medium 
0         
 50 1042 408 0.392 8.16 26.0 0.000
Test Chemical 3-Nitropropionic acid 
5         
 50 1045 453 0.433 9.06 26.0 10.711 
16         
 50 1048 508 0.485 10.16 26.0 23.797 
50         
 50 1050 592 0.564 11.84 26.0 43.993 
160         
 50 1047 707 0.675 14.14 26.0 72.457 
500         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Mitomycin-C 
 0.005     
 50 1044 1570 1.504 31.40 26.0 284.067
Mitomycin-C 
 0.01      
 50 1050 2754 2.623 55.08 26.0 569.857
Trend: 9.991        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 10/21/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1042 444 0.426 8.88 27.0 0.096
Medium 
0         
 50 1043 444 0.426 8.88 27.0 0.000
Test Chemical 3-Nitropropionic acid 
200         
 50 1040 667 0.641 13.34 32.0 50.659 
300         
 50 1031 772 0.749 15.44 32.0 75.898 
400         
 50 1046 885 0.846 17.70 32.0 98.753 
500         
 0 0 0 0.000 0.00 32.0 N/A
Positive Control Mitomycin-C 
 0.01      
 50 1042 3484 3.344 69.68 27.0 685.438
Trend: 12.064        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 09/11/1983    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1050 436 0.415 8.72 26.0 6.980
Medium 
0         
 50 1046 406 0.388 8.12 26.0 0.000
Test Chemical 3-Nitropropionic acid 
50         
 50 1049 402 0.383 8.04 26.0 -1.268 
160         
 50 1047 400 0.382 8.00 26.0 -1.572 
500         
 50 1049 414 0.395 8.28 26.0 1.679 
1600         
 50 1048 557 0.531 11.14 26.0 36.930 
5000         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Cyclophosphamide 
2         
 50 1043 2138 2.050 42.76 26.0 428.116
Trend: 4.736        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 11/21/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1038 394 0.380 7.88 26.0 3.385
Medium 
0         
 50 1035 380 0.367 7.60 26.0 0.000
Test Chemical 3-Nitropropionic acid 
1600         
 50 1048 457 0.436 9.14 26.0 18.771 
3000         
 50 1037 494 0.476 9.88 26.0 29.749 
4000         
 50 1042 507 0.487 10.14 26.0 32.525 
5000         
 50 1030 591 0.574 11.82 26.0 56.281
Positive Control Cyclophosphamide 
2         
 50 1037 1806 1.742 36.12 26.0 374.347
Trend: 6.696        
Probability: 0.000