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Study Information
Study Attribute Value
CEBS Accession Number: 002-01456-0001-0000-9
Chemical Name: 3-Sulfolene
CASRN: 77-79-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 067203_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 07/30/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1038 302 0.291 6.04 26.5 0.000
Test Chemical 3-Sulfolene 
379         
 50 1048 342 0.326 6.84 26.5 12.164 
1140         
 50 1046 336 0.321 6.72 26.5 10.407 
3790         
 50 1047 342 0.327 6.84 26.5 12.272
Positive Control Mitomycin-C 
 0.0015    
 50 1040 482 0.463 9.64 26.5 59.296
Mitomycin-C 
 0.01      
 10 207 234 1.130 23.40 26.5 288.540
Trend: 1.306        
Probability: 0.096        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 07/30/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1042 385 0.369 7.70 26.0 0.000
Test Chemical 3-Sulfolene 
379         
 50 1041 356 0.342 7.12 26.0 -7.444 
1140         
 50 1040 377 0.363 7.54 26.0 -1.890 
3790         
 50 1042 370 0.355 7.40 26.0 -3.896
Positive Control Cyclophosphamide 
 0.4       
 50 1046 576 0.551 11.52 26.0 49.038
Cyclophosphamide 
2.5       
 10 210 233 1.110 23.30 26.0 200.292
Trend: -0.281        
Probability: 0.611