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Study Information
Study Attribute Value
CEBS Accession Number: 002-01456-0002-0000-0
Chemical Name: 3-Sulfolene
CASRN: 77-79-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 067203_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 08/05/1985    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 6 0.030 3.0 2 0.010 1.0 4 0.020 2.0 0 0.000 0.0
Test Chemical: 3-Sulfolene 
368         
 200 4 0.020 2.0 1 0.005 1.0 3 0.015 2.0 0 0.000 0.0 
1110         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
3680         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
Positive Control: Mitomycin-C 
1         
 200 26 0.130 12.5 8 0.040 4.0 18 0.090 9.0 0 0.000 0.0
Mitomycin-C 
5         
 50 12 0.240 20.0 3 0.060 6.0 9 0.180 16.0 0 0.000 0.0
Trend: -2.057 -1.782 -1.400  
Probability: 0.980 0.963 0.919  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 08/05/1985    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 4 0.020 2.0 1 0.005 1.0 3 0.015 2.0 0 0.000 0.0
Test Chemical: 3-Sulfolene 
368         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
1110         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
3680         
 200 3 0.015 1.5 1 0.005 1.0 2 0.010 1.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
50         
 50 22 0.440 36.0 4 0.080 8.0 18 0.360 30.0 0 0.000 0.0
Trend: -0.487 0.018 -1.081  
Probability: 0.687 0.493 0.860