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Study Information
Study Attribute Value
CEBS Accession Number: 002-01456-0003-0000-1
Chemical Name: 3-Sulfolene
CASRN: 77-79-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 080941_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Test Failure 
Induced Rat Liver S9  2_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 02/04/1986    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1049 372 0.355 7.44 26.0 0.000
Test Chemical 3-Sulfolene 
160         
 50 1043 393 0.377 7.86 26.0 6.253 
500         
 50 1048 378 0.361 7.56 26.0 1.710 
1600         
 50 1046 404 0.386 8.08 26.0 8.914 
5000         
 50 1049 404 0.385 8.08 26.0 8.602
Positive Control Mitomycin-C 
 0.0E-4    
 50 1049 565 0.539 11.30 26.0 51.882
Mitomycin-C 
 0.005     
 10 211 266 1.261 26.60 26.0 255.494
Trend: 1.184        
Probability: 0.118        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 05/01/1986    Trial Call: Test Failure   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1047 535 0.511 10.70 26.0 0.000
Negative (Not Specified) 
0         
 50 1049 449 0.428 8.98 26.0 -16.235
Test Chemical 3-Sulfolene 
160         
 50 1046 471 0.450 9.42 26.0 -11.878 
500         
 50 1044 488 0.467 9.76 26.0 -8.523 
1600         
 50 1051 500 0.476 10.00 26.0 -6.898 
5000         
 50 1047 521 0.498 10.42 26.0 -2.617
Positive Control Cyclophosphamide 
 0.1       
 50 1046 583 0.557 11.66 26.0 9.076
Cyclophosphamide 
 0.6       
 10 210 238 1.133 23.80 26.0 121.794
Trend: -0.019        
Probability: 0.508        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 06/03/1986    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1048 462 0.441 9.24 26.0 0.000
Test Chemical 3-Sulfolene 
160         
 50 1041 515 0.495 10.30 26.0 12.221 
500         
 50 1049 467 0.445 9.34 26.0 0.986 
1600         
 50 1044 501 0.480 10.02 26.0 8.857 
5000         
 50 1045 517 0.495 10.34 26.0 12.226
Positive Control Cyclophosphamide 
 0.1       
 50 1052 600 0.570 12.00 26.0 29.376
Cyclophosphamide 
 0.6       
 10 209 235 1.124 23.50 26.0 155.059
Trend: 1.391        
Probability: 0.082