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Study Information
Study Attribute Value
CEBS Accession Number: 002-01456-0004-0000-2
Chemical Name: 3-Sulfolene
CASRN: 77-79-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 080941_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 05/13/1986    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Medium 
0         
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0
Test Chemical: 3-Sulfolene 
1600         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0 
3000         
 200 5 0.025 2.0 1 0.005 0.5 4 0.020 2.0 0 0.000 0.0 
5000         
 200 4 0.020 2.0 0 0.000 0.0 4 0.020 2.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.0625    
 200 45 0.225 21.0 15 0.075 7.5 30 0.150 13.5 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 38 0.760 44.0 16 0.320 24.0 22 0.440 34.0 0 0.000 0.0
Trend: 0.799 0.511 0.799  
Probability: 0.212 0.305 0.212  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 05/13/1986    Harvest Time: 13 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Medium 
0         
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0
Test Chemical: 3-Sulfolene 
1600         
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0 
3000         
 200 4 0.020 1.5 1 0.005 0.5 3 0.015 1.0 0 0.000 0.0 
5000         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Positive Control: Cyclophosphamide 
2.5       
 200 38 0.190 17.0 8 0.040 3.5 30 0.150 14.0 0 0.000 0.0
Cyclophosphamide 
7.5       
 50 24 0.480 40.0 8 0.160 16.0 16 0.320 28.0 0 0.000 0.0
Trend: -0.830 0.511 -1.046  
Probability: 0.797 0.305 0.852