COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-01459-0001-0000-2
Chemical Name: 4,4'-Diamino-2,2'-stilbenedisulfonic acid
CASRN: 81-11-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 610829_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 11/18/1986    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1044 340 0.326 6.80 26.5 0.000
Test Chemical 4,4'-Diamino-2,2'-stilbenedisulfonic acid 
102         
 50 1047 344 0.329 6.88 26.5 0.887 
306         
 50 1037 328 0.316 6.56 26.5 -2.878 
1020         
 50 1044 306 0.293 6.12 26.5 -10.000
Positive Control Mitomycin-C 
 0.0015    
 50 1044 448 0.429 8.96 26.5 31.765
Mitomycin-C 
 0.01      
 10 210 201 0.957 20.10 26.5 193.899
Trend: -1.421        
Probability: 0.922        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 11/18/1986    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1041 346 0.332 6.92 26.0 0.000
Test Chemical 4,4'-Diamino-2,2'-stilbenedisulfonic acid 
102         
 50 1040 305 0.293 6.10 26.0 -11.765 
306         
 50 1041 359 0.345 7.18 26.0 3.757 
1020         
 50 1041 318 0.305 6.36 26.0 -8.092
Positive Control Cyclophosphamide 
 0.5       
 50 1047 561 0.536 11.22 26.0 61.210
Cyclophosphamide 
2.5       
 10 208 324 1.558 32.40 26.0 368.658
Trend: -0.404        
Probability: 0.657