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Study Information
Study Attribute Value
CEBS Accession Number: 002-01459-0002-0000-3
Chemical Name: 4,4'-Diamino-2,2'-stilbenedisulfonic acid
CASRN: 81-11-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 610829_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 12/11/1986    Harvest Time: 10 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Medium 
0         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0
Test Chemical: 4,4'-Diamino-2,2'-stilbenedisulfonic acid 
101         
 200 6 0.030 3.0 2 0.010 1.0 3 0.015 1.5 1 0.005 1.0 
303         
 200 4 0.020 1.5 2 0.010 0.5 2 0.010 1.0 0 0.000 0.0 
1010         
 200 4 0.020 2.0 2 0.010 1.0 2 0.010 1.0 0 0.000 0.0
Positive Control: Mitomycin-C 
1         
 200 48 0.240 19.0 27 0.135 13.0 21 0.105 7.0 0 0.000 0.0
Mitomycin-C 
5         
 50 16 0.320 28.0 7 0.140 14.0 9 0.180 16.0 0 0.000 0.0
Trend: 0.732 0.377 0.849  
Probability: 0.232 0.353 0.198  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 12/11/1986    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Medium 
0         
 200 5 0.025 2.0 3 0.015 1.5 1 0.005 0.5 1 0.005 1.0
Test Chemical: 4,4'-Diamino-2,2'-stilbenedisulfonic acid 
101         
 200 5 0.025 1.5 1 0.005 0.5 4 0.020 1.5 0 0.000 0.0 
303         
 200 3 0.015 1.5 1 0.005 0.5 2 0.010 1.0 0 0.000 0.0 
1010         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
50         
 50 43 0.860 36.0 13 0.260 22.0 10 0.200 18.0 20 0.400 2.0
Trend: -1.722 -1.809 -0.745  
Probability: 0.957 0.965 0.772