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Study Information
Study Attribute Value
CEBS Accession Number: 002-01459-0003-0000-4
Chemical Name: 4,4'-Diamino-2,2'-stilbenedisulfonic acid
CASRN: 81-11-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 932349_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 09/27/1989    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1051 400 0.381 8.00 26.0 -2.532
Water 
0         
 50 1050 410 0.390 8.20 31.0 0.000
Test Chemical 4,4'-Diamino-2,2'-stilbenedisulfonic acid 
500         
 50 1051 427 0.406 8.54 26.0 4.047 
1667         
 50 1048 391 0.373 7.82 26.0 -4.452 
5000         
 50 1051 475 0.452 9.50 31.0 15.743
Positive Control Mitomycin-C 
 0.001     
 50 1050 643 0.612 12.86 26.0 56.829
Mitomycin-C 
 0.004     
 10 209 232 1.110 23.20 26.0 184.281
Trend: 1.681        
Probability: 0.046        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 09/27/1989    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1050 431 0.410 8.62 26.0 1.790
Water 
0         
 50 1044 421 0.403 8.42 31.0 0.000
Test Chemical 4,4'-Diamino-2,2'-stilbenedisulfonic acid 
500         
 50 1049 405 0.386 8.10 26.0 -4.259 
1667         
 50 1049 448 0.427 8.96 26.0 5.906 
5000         
 50 1050 457 0.435 9.14 31.0 7.931
Positive Control Cyclophosphamide 
 0.125     
 50 1047 540 0.516 10.80 26.0 27.899
Cyclophosphamide 
 0.5       
 10 211 200 0.948 20.00 26.0 135.053
Trend: 1.551        
Probability: 0.060