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Study Information
Study Attribute Value
CEBS Accession Number: 002-01459-0004-0000-5
Chemical Name: 4,4'-Diamino-2,2'-stilbenedisulfonic acid
CASRN: 81-11-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 932349_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 10/24/1989    Harvest Time: 15 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Water 
0         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 4,4'-Diamino-2,2'-stilbenedisulfonic acid 
1081         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0 
2325         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
5000         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.4       
 25 25 1.000 64.0 13 0.520 48.0 12 0.480 32.0 0 0.000 0.0
Trend: 0.633 0.633 0.000  
Probability: 0.263 0.263 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 10/24/1989    Harvest Time: 12.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Water 
0         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
Test Chemical: 4,4'-Diamino-2,2'-stilbenedisulfonic acid 
1081         
 200 13 0.065 2.0 3 0.015 1.5 0 0.000 0.0 10 0.050 0.5 
2325         
 200 3 0.015 1.5 3 0.015 1.5 0 0.000 0.0 0 0.000 0.0 
5000         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Positive Control: Cyclophosphamide 
20         
 25 23 0.920 56.0 18 0.720 44.0 5 0.200 20.0 0 0.000 0.0
Trend: -0.569 0.000 -0.776  
Probability: 0.715 0.500 0.781