Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01459-0004-0000-5 |
Chemical Name: | 4,4'-Diamino-2,2'-stilbenedisulfonic acid |
CASRN: | 81-11-8 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 932349_CA |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Water | 0 | 200 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
Test Chemical: | 4,4'-Diamino-2,2'-stilbenedisulfonic acid | 1081 | 200 | 1 | 0.005 | 0.5 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
2325 | 200 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
5000 | 200 | 1 | 0.005 | 0.5 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.4 | 25 | 25 | 1.000 | 64.0 | 13 | 0.520 | 48.0 | 12 | 0.480 | 32.0 | 0 | 0.000 | 0.0 |
Trend: | 0.633 | 0.633 | 0.000 | ||||||||||||
Probability: | 0.263 | 0.263 | 0.000 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Water | 0 | 200 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
Test Chemical: | 4,4'-Diamino-2,2'-stilbenedisulfonic acid | 1081 | 200 | 13 | 0.065 | 2.0 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 | 10 | 0.050 | 0.5 |
2325 | 200 | 3 | 0.015 | 1.5 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
5000 | 200 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 20 | 25 | 23 | 0.920 | 56.0 | 18 | 0.720 | 44.0 | 5 | 0.200 | 20.0 | 0 | 0.000 | 0.0 |
Trend: | -0.569 | 0.000 | -0.776 | ||||||||||||
Probability: | 0.715 | 0.500 | 0.781 |