COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-01462-0001-0000-6
Chemical Name: 4,4'-Dimethoxydiphenylamine
CASRN: 101-70-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 918738_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 02/18/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1029 372 0.362 7.44 27.0 0.000
Test Chemical 4,4'-Dimethoxydiphenylamine 
1.27      
 50 1046 442 0.423 8.84 27.0 16.886 
3.8       
 50 1035 460 0.444 9.20 27.0 22.939 
12.7       
 50 1029 632 0.614 12.64 27.0 69.892 
38         
 0 0 0 0.000 0.00 27.0 N/A
Positive Control Mitomycin-C 
 0.002     
 50 1032 529 0.513 10.58 27.0 41.791
Mitomycin-C 
 0.01      
 10 209 185 0.885 18.50 27.0 144.849
Trend: 8.306        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 04/07/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1026 404 0.394 8.08 26.0 0.000
Test Chemical 4,4'-Dimethoxydiphenylamine 
10         
 50 1030 698 0.678 13.96 26.0 72.101 
15         
 50 1025 645 0.629 12.90 26.0 59.809 
20         
 50 1030 698 0.678 13.96 26.0 72.101 
30         
 0 0 0 0.000 0.00 30.0 N/A
Positive Control Mitomycin-C 
 0.002     
 100 2053 1043 0.508 10.43 26.0 29.021
Mitomycin-C 
 0.01      
 10 206 212 1.029 21.20 26.0 161.357
Trend: 7.508        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 02/18/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1031 420 0.407 8.40 26.0 0.000
Test Chemical 4,4'-Dimethoxydiphenylamine 
38         
 50 1025 506 0.494 10.12 26.0 21.181 
127         
 50 1029 795 0.773 15.90 26.0 89.654 
380         
 50 1042 692 0.664 13.84 26.0 63.023 
1270         
 50 1042 775 0.744 15.50 30.0 82.576
Positive Control Cyclophosphamide 
 0.5       
 50 1047 512 0.489 10.24 26.0 20.042
Cyclophosphamide 
2.5       
 10 211 199 0.943 19.90 26.0 131.515
Trend: 10.986        
Probability: 0.000