Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01462-0002-0000-7 |
Chemical Name: | 4,4'-Dimethoxydiphenylamine |
CASRN: | 101-70-2 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 918738_CA |
Study Result: | Weakly Positive |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Questionable |
No Activation | 2 | Weakly Positive |
Induced Rat Liver S9 | 2_S9 | Questionable |
No Activation | 3 | Questionable |
Induced Rat Liver S9 | 3_S9 | Test Failure |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 200 | 7 | 0.035 | 3.0 | 1 | 0.005 | 0.5 | 6 | 0.030 | 2.5 | 0 | 0.000 | 0.0 |
Test Chemical: | 4,4'-Dimethoxydiphenylamine | 159 | 200 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
530 | 200 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | ||
1590 | 200 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 1 | 50 | 52 | 1.040 | 44.0 | 8 | 0.160 | 16.0 | 24 | 0.480 | 28.0 | 20 | 0.400 | 2.0 |
Mitomycin-C | 5 | 50 | 64 | 1.280 | 56.0 | 17 | 0.340 | 30.0 | 27 | 0.540 | 32.0 | 20 | 0.400 | 2.0 | |
Trend: | -2.884 | -1.346 | -2.562 | ||||||||||||
Probability: | 0.998 | 0.911 | 0.995 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 200 | 10 | 0.050 | 4.0 | 3 | 0.015 | 1.5 | 7 | 0.035 | 3.0 | 0 | 0.000 | 0.0 |
Test Chemical: | 4,4'-Dimethoxydiphenylamine | 132 | 200 | 44 | 0.220 | 11.5 | 16 | 0.080 | 7.5 | 18 | 0.090 | 6.5 | 10 | 0.050 | 1.0 |
440 | 200 | 36 | 0.180 | 8.5 | 9 | 0.045 | 4.5 | 17 | 0.085 | 5.0 | 10 | 0.050 | 1.0 | ||
1320 | 200 | 11 | 0.055 | 5.5 | 5 | 0.025 | 2.5 | 6 | 0.030 | 3.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 50 | 50 | 34 | 0.680 | 40.0 | 8 | 0.160 | 16.0 | 16 | 0.320 | 26.0 | 10 | 0.200 | 1.0 |
Trend: | 0.193 | 0.007 | -0.222 | ||||||||||||
Probability: | 0.423 | 0.497 | 0.588 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 200 | 3 | 0.015 | 1.5 | 2 | 0.010 | 1.0 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 |
Test Chemical: | 4,4'-Dimethoxydiphenylamine | 504 | 200 | 15 | 0.075 | 4.5 | 3 | 0.015 | 1.5 | 12 | 0.060 | 3.0 | 0 | 0.000 | 0.0 |
1501 | 200 | 17 | 0.085 | 4.5 | 9 | 0.045 | 2.0 | 8 | 0.040 | 3.5 | 0 | 0.000 | 0.0 | ||
2498 | 200 | 17 | 0.085 | 7.5 | 6 | 0.030 | 2.5 | 11 | 0.055 | 5.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.2 | 200 | 52 | 0.260 | 22.0 | 21 | 0.105 | 10.5 | 29 | 0.145 | 13.5 | 2 | 0.010 | 2.0 |
Mitomycin-C | 5 | 50 | 287 | 5.740 | 98.0 | 49 | 0.980 | 56.0 | 45 | 0.900 | 50.0 | 193 | 3.860 | 22.0 | |
Trend: | 2.627 | 1.196 | 2.547 | ||||||||||||
Probability: | 0.004 | 0.116 | 0.005 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 200 | 14 | 0.070 | 4.0 | 5 | 0.025 | 1.5 | 9 | 0.045 | 3.5 | 0 | 0.000 | 0.0 |
Test Chemical: | 4,4'-Dimethoxydiphenylamine | 264 | 200 | 28 | 0.140 | 10.0 | 10 | 0.050 | 4.0 | 18 | 0.090 | 7.0 | 0 | 0.000 | 0.0 |
530 | 200 | 19 | 0.095 | 5.5 | 5 | 0.025 | 2.0 | 13 | 0.065 | 4.0 | 1 | 0.005 | 1.0 | ||
795 | 200 | 26 | 0.130 | 8.0 | 11 | 0.055 | 3.5 | 14 | 0.070 | 6.0 | 1 | 0.005 | 1.0 | ||
1060 | 200 | 15 | 0.075 | 7.5 | 5 | 0.025 | 2.5 | 10 | 0.050 | 5.0 | 0 | 0.000 | 0.0 | ||
1590 | 0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 50 | 50 | 24 | 0.480 | 28.0 | 12 | 0.240 | 20.0 | 12 | 0.240 | 16.0 | 0 | 0.000 | 0.0 |
Trend: | 0.762 | 0.374 | 0.339 | ||||||||||||
Probability: | 0.223 | 0.354 | 0.367 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 200 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
Test Chemical: | 4,4'-Dimethoxydiphenylamine | 560 | 200 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 |
1130 | 200 | 4 | 0.020 | 0.5 | 3 | 0.015 | 0.5 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | ||
1690 | 300 | 45 | 0.150 | 2.7 | 3 | 0.010 | 0.7 | 2 | 0.007 | 0.7 | 40 | 0.133 | 4.0 | ||
Positive Control: | Mitomycin-C | 0.2 | 200 | 106 | 0.530 | 33.0 | 62 | 0.310 | 25.5 | 33 | 0.165 | 12.0 | 11 | 0.055 | 2.0 |
Mitomycin-C | 5 | 10 | 85 | 8.500 | 100.0 | 2 | 0.200 | 10.0 | 2 | 0.200 | 10.0 | 81 | 8.100 | 9.0 | |
Trend: | 2.722 | 1.555 | 1.047 | ||||||||||||
Probability: | 0.003 | 0.060 | 0.148 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 200 | 18 | 0.090 | 7.5 | 3 | 0.015 | 1.5 | 10 | 0.050 | 4.0 | 5 | 0.025 | 5.0 |
Test Chemical: | 4,4'-Dimethoxydiphenylamine | 128 | 200 | 32 | 0.160 | 13.0 | 8 | 0.040 | 4.0 | 21 | 0.105 | 9.5 | 3 | 0.015 | 3.0 |
253 | 200 | 26 | 0.130 | 10.5 | 11 | 0.055 | 5.5 | 11 | 0.055 | 4.5 | 4 | 0.020 | 4.0 | ||
505 | 200 | 27 | 0.135 | 10.5 | 3 | 0.015 | 1.5 | 21 | 0.105 | 9.0 | 3 | 0.015 | 3.0 | ||
760 | 200 | 47 | 0.235 | 17.0 | 12 | 0.060 | 4.5 | 27 | 0.135 | 11.5 | 8 | 0.040 | 8.0 | ||
1010 | 200 | 29 | 0.145 | 12.0 | 9 | 0.045 | 4.5 | 17 | 0.085 | 6.5 | 3 | 0.015 | 3.0 | ||
Positive Control: | Cyclophosphamide | 50 | 50 | 37 | 0.740 | 42.0 | 10 | 0.200 | 18.0 | 12 | 0.240 | 22.0 | 15 | 0.300 | 6.0 |
Trend: | 1.825 | 1.015 | 1.617 | ||||||||||||
Probability: | 0.034 | 0.155 | 0.053 |