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Study Information
Study Attribute Value
CEBS Accession Number: 002-01463-0001-0000-7
Chemical Name: 4,4'-Dioctyldiphenylamine
CASRN: 101-67-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 605345_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Weakly Positive 
Induced Rat Liver S9  2_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 04/01/1986    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Acetone 
0         
 50 1037 419 0.404 8.38 26.5 0.000
Test Chemical 4,4'-Dioctyldiphenylamine 
85.5       
 50 1034 473 0.457 9.46 26.5 13.215 
257         
 50 1040 378 0.363 7.56 26.5 -10.045 
855         
 50 1036 450 0.434 9.00 26.5 7.502
Positive Control Mitomycin-C 
 0.002     
 50 1045 557 0.533 11.14 26.5 31.918
Mitomycin-C 
 0.01      
 10 209 272 1.301 27.20 26.5 222.097
Trend: 0.016        
Probability: 0.494        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 04/01/1986    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Acetone 
0         
 50 1041 435 0.418 8.70 26.0 0.000
Test Chemical 4,4'-Dioctyldiphenylamine 
85.5       
 50 1044 483 0.463 9.66 26.0 10.715 
257         
 50 1046 490 0.468 9.80 26.0 12.105 
855         
 50 1045 532 0.509 10.64 26.0 21.831
Positive Control Cyclophosphamide 
 0.5       
 50 1036 576 0.556 11.52 26.0 33.053
Cyclophosphamide 
2.5       
 10 209 230 1.100 23.00 26.0 163.356
Trend: 2.970        
Probability: 0.001        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 06/11/1986    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Acetone 
0         
 50 1048 479 0.457 9.58 25.0 0.000
Test Chemical 4,4'-Dioctyldiphenylamine 
1120         
 50 1044 431 0.413 8.62 25.0 -9.676 
1690         
 50 1049 470 0.448 9.40 25.0 -1.972 
3370         
 50 1048 513 0.490 10.26 25.0 7.098
Positive Control Cyclophosphamide 
 0.5       
 50 1046 1008 0.964 20.16 25.0 110.841
Cyclophosphamide 
2.5       
 10 209 589 2.818 58.90 25.0 516.588
Trend: 1.477        
Probability: 0.070