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Study Information
Study Attribute Value
CEBS Accession Number: 002-01463-0002-0000-8
Chemical Name: 4,4'-Dioctyldiphenylamine
CASRN: 101-67-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 605345_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 04/08/1986    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Acetone 
0         
 200 6 0.030 3.0 1 0.005 0.5 5 0.025 2.5 0 0.000 0.0
Test Chemical: 4,4'-Dioctyldiphenylamine 
445         
 200 11 0.055 4.0 2 0.010 1.0 9 0.045 3.5 0 0.000 0.0 
1340         
 200 7 0.035 3.5 2 0.010 1.0 5 0.025 2.5 0 0.000 0.0 
4450         
 200 7 0.035 3.5 2 0.010 1.0 5 0.025 2.5 0 0.000 0.0
Positive Control: Mitomycin-C 
1         
 200 74 0.370 26.5 17 0.085 8.5 57 0.285 19.5 0 0.000 0.0
Mitomycin-C 
5         
 50 35 0.700 44.0 3 0.060 6.0 32 0.640 38.0 0 0.000 0.0
Trend: 0.173 0.508 -0.190  
Probability: 0.431 0.306 0.575  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 04/08/1986    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Acetone 
0         
 200 5 0.025 2.0 2 0.010 1.0 3 0.015 1.5 0 0.000 0.0
Test Chemical: 4,4'-Dioctyldiphenylamine 
445         
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 
1340         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
4450         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
50         
 50 25 0.500 30.0 10 0.200 16.0 15 0.300 22.0 0 0.000 0.0
Trend: -2.553 -1.802 -2.232  
Probability: 0.995 0.964 0.987